ACE2 Antibody, clone 4G5.1 | EMD Millipore MABN59 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

ACE2 Antibody, clone 4G5.1

catalog :

MABN59

quantity :

100 µL

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

4G5.1

reactivity :

human

application :

western blot

product information

Catalog Number :

MABN59

Subcategory :

Cell Signaling

Product Name :

Anti-ACE2 Antibody, clone 4G5.1

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

Q9BYF1

Host Name :

Mouse

Antigen :

ACE2

Clone :

4G5.1

Conjugate :

Purified

Isotype :

IgG1κ

Product Description :

Anti-ACE2 Antibody, clone 4G5.1

Cross Reactivity :

Human

Background :

ACE2 (Angiotensin-converting enzyme 2) is a transmembrane protein belonging to the peptidase M2 family. It is expressed in vascular endothelial cells of the heart, kidney, testis, and gastrointestinal system. ACE2 produces Angiotensin (1-9) by hydrolysis of Angiotensin 1. Angiotensin (1-9) is a precursor for Angiotensin (1-7). ACE2 may also directly produce Angiotensin (1-7) by conversion of Angiotensin II, which is involved in vasoconstriction. Angiotensin (1-7) plays an important role in the RAS signaling pathway and is involved in vasodilation. Hence, ACE2 antagonizes the effects of its homolog, ACE. ACE2 is insensitive to commonly used inhibitors such as linosipril and captopril. ACE2 is upregulated in heart failure, possibly in response to overactivity of Angiotensin II; ACE2 is studied for its potential therapeutic value for hypertension and heart failure.

ALT Names :

Angiotensin-converting enzyme 2;ACE-related carboxypeptidase;Angiotensin-converting enzyme homolog;ACEH; Metalloprotease MPROT15

Immunogen :

GST-tagged recombinant protein corresponding to human ACE2.

Specificity :

This antibody recognizes ACE2.

Package Size :

100 µL

Uses :

Western Blotting

Storage :

Stable for 1 year at 2-8°C from date of receipt