Gs protein Antibody, alpha subunit, clone N192/12 | EMD Millipore MABN543 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Gs protein Antibody, alpha subunit, clone N192/12

catalog :

MABN543

quantity :

100 μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

N192/12

The same clone is also sold as:

Neuromab: 73-211, 75-211
OriGene: 75-211, 73-211

reactivity :

human, bovine

application :

western blot

product information

Catalog Number :

MABN543

Subcategory :

Neuroscience

Product Name :

Anti-Gs protein Antibody, alpha subunit, clone N192/12

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P04896

Host Name :

Mouse

Antigen :

Gs protein

Clone :

N192/12

Conjugate :

Purified

Isotype :

IgG1κ

Product Description :

Anti-Gs protein Antibody, alpha subunit, clone N192/12

Cross Reactivity :

Human;Rat

Background :

The heterotrimeric guanine nucleotide-binding regulatory proteins (G proteins) mediate signaling from a large number of G-protein coupled receptors (GPCR) to a variety of intracellular effectors. G-proteins are composed of a 36-52 kDa α-subunit, a 35-36 kDa β-subunit, and an 8-10 kDa γ-subunit. They are classified based on the nature of their α-subunit. Gs is ubiquitously expressed and couples receptors to adenylyl cyclase and promotes intracellular cAMP generation. Mutations in Gs-α can lead to constitutive activation of receptors leading to development of endocrine tumors, fibrous dysplasia of bone, and McCune-Albright syndrome. In brain tissue Gs-α activates adenyl cyclase in direct response to stimulation of several neurotransmitter receptors and facilitates depolarization-induced neurotransmitter release for synaptic transmission. Also, it is shown that Gs-stimulated adenylyl cyclase activity is significantly reduced in the Alzheimer's disease brain tissue.

ALT Names :

Guanine nucleotide-binding protein G(s) subunit alpha isoforms short;Adenylate cyclase-stimulating G alpha protein

Immunogen :

Recombinant protein corresponding to bovine GS protein, alpha subunit.

Package Size :

100 μg

Uses :

Western Blotting

Storage :

Stable for 1 year at 2-8°C from date of receipt