Neuregulin-CRD, Type III Antibody, clone N126B/31 | EMD Millipore MABN534 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Neuregulin-CRD, Type III Antibody, clone N126B/31

catalog :

MABN534

quantity :

100 μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

N126B/31

The same clone is also sold as:

OriGene: 75-226, 73-226
Neuromab: 73-226, 75-226

reactivity :

human

application :

western blot, immunohistochemistry

product information

Catalog Number :

MABN534

Subcategory :

Neuroscience

Product Name :

Anti-Neuregulin-CRD, Type III Antibody, clone N126B/31

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

Q96IB3

Host Name :

Mouse

Antigen :

Neuregulin-CRD

Conjugate :

Purified

Isotype :

IgG2b

Product Description :

Anti-Neuregulin-CRD, Type III Antibody, clone N126B/31

Cross Reactivity :

Human

Background :

Cysteine-rich domain (CRD), Type III belongs to the Neuregulin-1(NRG1) family of proteins, which are cell-cell signaling molecules and are ligands for receptor tyrosine kinases of the ErbB/HER subfamily. Type III NRG1 proteins (defined by the N-terminal cysteine-rich domain (CRD), also referred to as CRD-NRG1 proteins) play a critical role in neural development, including myelination, motor and sensory neuron survival, and neuromuscular synapse development . Defects in animals lacking type III NRGs include retraction of nerve terminals from newly formed synapses, absence of Schwann cells from peripheral nerves, and loss of motor and sensory neurons. Available evidence indicates that most Type III NRG1 proteins are synthesized as transmembrane proteins with 2 TM domains, and that proteolytic processing produces a bioactive transmembrane form (NTFm) which serves as a juxtacrine signal.

ALT Names :

Neuregulin 1

Immunogen :

Recombinant protein corresponding to the N-terminus of human Neuregulin-CRD, Type III.

Specificity :

This antibody recognizes the N-terminus of Neuregulin-CRD, Type III.

Package Size :

100 μg

Uses :

Immunohistochemistry;Western Blotting

Storage :

Stable for 1 year at 2-8°C from date of receipt