nNOS/NOS I Antibody, clone 2G1.1 | EMD Millipore MABN533 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

nNOS/NOS I Antibody, clone 2G1.1

catalog :

MABN533

quantity :

100 μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

2G1.1

reactivity :

human

application :

western blot, immunohistochemistry, immunohistochemistry - paraffin section

product information

Catalog Number :

MABN533

Subcategory :

Neuroscience

Product Name :

Anti-nNOS/NOS I Antibody, clone 2G1.1

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P29475

Host Name :

Mouse

Antigen :

NOS1

Clone :

2G1.1

Conjugate :

Purified

Purification Method :

Protein G purified

Isotype :

IgG1κ

Product Description :

Anti-nNOS/NOS I Antibody, clone 2G1.1

Cross Reactivity :

Human

Background :

Nitric oxide (NO) is an inorganic, gaseous free radical that carries a variety of messages between cells. nNOS/NOS I, also known as NC-NOS, or NOS type I, or Neuronal NOS, or Peptidyl-cysteine S-nitrosylase NOS1 and bNOS produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. NOS I has been suggested to have nitrosylase activity and to mediate cysteine S-nitrosylation of cytoplasmic target proteins such SRR. Vasorelaxation, neurotransmission and cytotoxicity can all be potentiated through cellular response to NO. NO production is mediated by members of the nitric oxide synthase (NOS) family. NOS catalyzes the oxidization of L-arginine to produce L-citrulline and NO. Two constitutive isoforms, brain or neuronal NOS (b or nNOS, type I) & endothelial cell NOS (eNOS, type III), and one inducible isoform (iNOS, type II), have been cloned. Cytokines such as interferon-gamma (IFN), tumor necrosis factor (TNF), interleukin-1 and -2, and lipopolysaccarides (LPS) cause an increase in iNOS mRNA, protein, and activity levels. Protein kinase C-stimulating agents exhibit the same effect on iNOS activity. Human iNOS is regulated by calcium/calmodulin (in contrast with mouse NOS2).

ALT Names :

Nitric oxide synthase, brain, Constitutive NOS, NC-NOS, NOS type I, Neuronal NOS, N-NOS, nNOS, Peptidyl-cysteine S-nitrosylase NOS1, bNOS

Immunogen :

Recombinant protein corresponding to Human nNOS/NOS I.

Package Size :

100 μg

Uses :

Western Blotting, Immunohistochemistry (Paraffin)

Storage :

Stable for 1 year at 2-8°C from date of receipt