Tau Antibody, PAD, clone TNT-1 | EMD Millipore MABN471 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Tau Antibody, PAD, clone TNT-1

catalog :

MABN471

quantity :

100 μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

TNT-1

reactivity :

human, mouse, rat

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, enzyme immunoassay

product information

Catalog Number :

MABN471

Subcategory :

Neuroscience

Product Name :

Anti-Tau Antibody, PAD, clone TNT-1

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P10636

Host Name :

Mouse

Antigen :

Tau

Clone :

TNT-1

Conjugate :

Purified

Isotype :

IgG1κ

Product Description :

Anti-Tau Antibody, PAD, clone TNT-1

Cross Reactivity :

Human;Mouse;Rat

Background :

Tau or Microtubule-associated protein tau (MAPT), also known as neurofibrillary tangle protein and paired helical filament-tau (PHF-tau), is a cytosolic protein that promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of axonal polarity in neurons. Tau binds to and is thought to function as a linker protein between axonal microtubules and neural plasma membrane components. There are multiple isoforms, and the short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. PAD is the phosphatase activating domain, and has been demonstrated to be involved in the inhibition of anterograde, kinesin-based fast axonal transport (FAT) by activating axonal protein phosphatase 1 (PP1) and glycogen synthase kinase 3 (GSK3), independent of microtubule binding. Defects in Tau are thought to be the cause of a number of neurodegenerative diseases, including frontotemporal dementia (FTD), pallido-ponto-nigral degeneration (PPND), Pick disease of the brain (PIDB), corticobasal degeneration (CBD), supranuclear palsy type 1 (PSNP1), Alzheimer disease, and Parkinson disease.

ALT Names :

Microtubule-associated protein tau;Neurofibrillary tangle protein;Paired helical filament-tau;PHF-tau;Tau, phosphatase activating domain

Immunogen :

KLH-conjugated linear peptide corresponding to human Tau.

Package Size :

100 μg

Uses :

Western Blotting;Immunohistochemistry;Dot Blot;Immunofluorescence;Enzyme Immunoassay (ELISA)

Storage :

Stable for 1 year at 2-8°C from date of receipt