Dopamine D3 receptor Antibody, clone N331/19 | EMD Millipore MABN463 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Dopamine D3 receptor Antibody, clone N331/19

catalog :

MABN463

quantity :

100 μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

N331/19

The same clone is also sold as:

OriGene: 73-301
Neuromab: 73-301
BioLegend: 827501

reactivity :

human, rat

application :

immunohistochemistry, immunocytochemistry

product information

Catalog Number :

MABN463

Subcategory :

Neuroscience

Product Name :

Anti-Dopamine D3 receptor Antibody, clone N331/19

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P35462

Host Name :

Mouse

Antigen :

Dopamine D3 receptor

Clone :

N331/19

Conjugate :

Purified

Isotype :

IgG2aκ

Product Description :

Anti-Dopamine D3 receptor Antibody, clone N331/19

Cross Reactivity :

Rat;Human

Background :

Dopamine is a widely distributed neurotransmitter produced by hydroxylation of L-tyrosine, followed by decarboxylation with DOPA decarboxylase. Dopamine exerts its actions by interacting with multiple classes of dopamine receptors that belong to the family of G protein-coupled receptors. Thus far five dopamine receptor subtypes have been reported that are classified into two main families based on their sequence and similarity in signal role. The D1-like dopamine receptors include the dopamine receptors D1 and D5. Binding of dopamine to these receptors leads to the activation of adenylyl cyclase, via a Gs protein, leading to increased cAMP production. The dopamine D2-like receptor group consists of D2, D3, and D4 receptors, which are coupled to Gi/o proteins and act by inhibiting adenylyl cyclase activity. D3 receptor subtype was first cloned and characterized by Sokoloff et al in 1990 (Nature 347, pp 146-151). D3 receptor coupling to various signal transduction mechanisms usually mimic those of D2 receptors, however, their cerebral distribution is very different. Highest expression of D3 receptors is found in ventral striatum in human brain. Dopamine D3 receptor represents a potential target for development of drugs to treat various neuropsychiatric and neurological disorders such as schizophrenia, Parkinson’s disease, drugs of abuse.

ALT Names :

D(3) dopamine receptor;Dopamine D3 receptor

Immunogen :

Recombinant protein corresponding to human Dopamine D3 receptor.

Package Size :

100 μg

Uses :

Immunohistochemistry;Immunocytochemistry

Storage :

Stable for 1 year at 2-8°C from date of receipt