CHRDL1 Antibody, clone 10C9.3 | EMD Millipore MABN453 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

CHRDL1 Antibody, clone 10C9.3

catalog :

MABN453

quantity :

100 μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

10C9.3

reactivity :

human, rat

application :

western blot, immunohistochemistry

citations: 2

Reference
Blanco Suarez E, Liu T, Kopelevich A, Allen N. Astrocyte-Secreted Chordin-like 1 Drives Synapse Maturation and Limits Plasticity by Increasing Synaptic GluA2 AMPA Receptors. Neuron. 2018;100:1116-1132.e13 pubmed publisher
Garcia Alvarez G, Lu B, Yap K, Wong L, Thevathasan J, Lim L, et al. STIM2 regulates PKA-dependent phosphorylation and trafficking of AMPARs. Mol Biol Cell. 2015;26:1141-59 pubmed publisher

product information

Catalog Number :

MABN453

Subcategory :

Neuroscience

Product Name :

Anti-CHRDL1 Antibody, clone 10C9.3

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

Q9BU40

Host Name :

Mouse

Antigen :

CHRDL1

Clone :

10C9.3

Conjugate :

Purified

Purification Method :

Protein G purified

Isotype :

IgG1κ

Product Description :

Anti-CHRDL1 Antibody, clone 10C9.3

Cross Reactivity :

Human, Rat

Background :

Chordin-like protein 1 (CHRDL1) is an important secreted developmental mediator protein expressed in developing cornea, retina, brain, cerebellum and neocortex and developing bone. CHRDL1 in the nervous system alters the fate commitment of neural stem cells from gliogenesis to neurogenesis and contributes to neuronal differentiation of neural stem cells in the brain by the preventing the adoption of a glial fate. CHRDL1 also plays a critical role in dorsventral axis formation and regulates the action of BMP4 and preventing it from interacting with its receptors. In the developing eye CHRDL1 regulates retinal angiogenesis and the development of the anterior segment of the eye. Mutations in CHRDL1 are associated with various eye disorders and in particular one named Megalocornea 1, an X-linked developmental disease.

ALT Names :

Chordin-like protein 1, Neuralin-1, Neurogenesin-1, Ventroptin

Immunogen :

KLH-conjugated linear peptide corresponding to human CHRDL1.

Package Size :

100 μg

Uses :

Western Blotting, Immunohistochemistry

Storage :

Stable for 1 year at 2-8°C from date of receipt