Adenosine Deaminase Antibody, clone 9H12.1 | EMD Millipore MABN452 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Adenosine Deaminase Antibody, clone 9H12.1

catalog :

MABN452

quantity :

200 µL

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

9H12.1

reactivity :

human

application :

western blot, immunohistochemistry, immunohistochemistry - paraffin section

product information

Catalog Number :

MABN452

Subcategory :

Neuroscience

Product Name :

Anti-Adenosine Deaminase Antibody, clone 9H12.1

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

Q9NZK5

Host Name :

Mouse

Antigen :

CECR1

Clone :

9H12.1

Conjugate :

Purified

Purification Method :

Purified by ion-exchange chromatography

Isotype :

IgMκ

Product Description :

Anti-Adenosine Deaminase Antibody, clone 9H12.1

Cross Reactivity :

Human

Background :

Adenosine deaminase, also known as ADA, or Cat eye syndrome critical region protein 1, and encoded by the gene CECR1/ADA2/ADGF/IDGFL, is an extracellular enzyme that works on adenosine and causes the degradation of adenosine to inosine and free NH3. Adenosine deaminase is an extracellular secreted enzyme that binds to cell surfaces via proteoglycans. The binding appears to mediate cellular proliferation and differentiation in many systems, though this activity is independent of its deaminase activity. Adenosine deaminase is highly present in blood plasma and widely expressed in adult and fetal tissues. While there many clinical deficiencies associated with adenosine deaminase (ADA) mutations, the level of ADA activity in the blood and fluids is used as a biomarker to help distinguish various diseases. For instance, the level of activity in lung fluid is correlated with tuberculosis infection and used to distinguish it from malignant pleural effusion (MPE). The ADA level in CSF in patients with meningitis also helps to identify tuberculosis as the cause as opposed to another agent or condition.

ALT Names :

Adenosine deaminase CECR1, Cat eye syndrome critical region protein 1, CECR1

Immunogen :

GST-tagged recombinant protein corresponding to human Adenosine Deaminase.

Package Size :

200 µL

Uses :

Western Blotting, Immunohistochemistry (Paraffin)

Storage :

Stable for 1 year at 2-8°C from date of receipt