RAB27A Antibody, clone 16H2.1 | EMD Millipore MABN446 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

RAB27A Antibody, clone 16H2.1

catalog :

MABN446

quantity :

100 μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

16H2.1

reactivity :

human

application :

western blot, immunohistochemistry, immunohistochemistry - paraffin section

product information

Catalog Number :

MABN446

Subcategory :

Neuroscience

Product Name :

Anti-RAB27A Antibody, clone 16H2.1

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P51159

Host Name :

Mouse

Antigen :

RAB27A

Clone :

16H2.1

Conjugate :

Purified

Isotype :

IgG1κ

Product Description :

Anti-RAB27A Antibody, clone 16H2.1

Cross Reactivity :

Human

Background :

RAB27A, also known as Rab-27 or GTP-binding protein Ram, and encoded by the gene RAB27A/RAB27, plays a role in cytotoxic granule exocytosis in lymphocytes. RAB27A is required for both granule maturation and granule docking and priming at the immunologic synapse. Additionally, RAB27A binds SYTL1, SLAC2B, MYRIP, SYTL3, SYTL4 and SYTL5, and it interacts with RPH3A and RPH3A as well as MLPH and SYTL2. RAB27A is localized to the membrane bound in lipid-anchors, and it is also found in melanosomes and lysosomes and localizes to endosomal exocytic vesicles. RAB27A is expressed in all tissues examined except in brain. Low expression is found in thymus, kidney, muscle and placenta. RAB27A is detected in melanocytes, and in most tumor cell lines examined. RAB27A is expressed in cytotoxic T-lymphocytes (CTL) and mast cells. Defects in RAB27A may be associated with Griscelli syndrome 2 a rare autosomal recessive disorder that results in pigmentary dilution of the skin and hair, the presence of large clumps of pigment in hair shafts, and an accumulation of melanosomes in melanocytes. GS2 patients also develop an uncontrolled T-lymphocyte and macrophage activation syndrome, known as hemophagocytic syndrome, leading to death in the absence of bone marrow transplantation. Neurological impairment is present in some patients, likely as a result of hemophagocytic syndrome.

ALT Names :

Ras related protein Rab-27A;Rab-27;GTP-binding protein Ram

Immunogen :

KLH-conjugated linear peptide corresponding to human RAB27A.

Package Size :

100 μg

Uses :

Western Blotting;Immunohistochemistry (Paraffin)

Storage :

Stable for 1 year at 2-8°C from date of receipt