Apolipoprotein E4 (ApoE4) Antibody, clone 4E4 | EMD Millipore MABN43 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Apolipoprotein E4 (ApoE4) Antibody, clone 4E4

catalog :

MABN43

quantity :

100 µL

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

4E4

The same clone is also sold as:

Invitrogen: MA5-16146, MA5-18068
Cell Signaling Technology: 8941
Enzo Life Sciences: ENZ-ABS295-0100
ImmuQuest: IQ552
LifeSpan Biosciences: LS-C143457, LS-C143458, LS-B12188, LS-C143461, LS-C143459

reactivity :

human

application :

western blot, immunohistochemistry, immunoprecipitation

product information

Catalog Number :

MABN43

Subcategory :

Neuroscience

Product Name :

Anti-Apolipoprotein E4 (ApoE4) Antibody, clone 4E4

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P02649

Host Name :

Mouse

Antigen :

Apolipoprotein E4 (ApoE4)

Clone :

4E4

Conjugate :

Purified

Isotype :

IgG1κ

Product Description :

Anti-Apolipoprotein E4 (ApoE4) Antibody, clone 4E4

Cross Reactivity :

Human

Background :

Apolipoprotein is a polymorphic plasma protein that exists as three isoforms: ApoE4, ApoE3, and ApoE2, which differ in the combination of cysteine and arginine residues located at position 122 and 158. The 35 kDa ApoE4 isoform contains arginine at both locations, and is produced in the liver and brain, although it is widely expressed in other tissues, such as the lung, spleen, and ovary. Like other isoforms, ApoE4 is a ligand for low density lipoprotein receptors (LDL) and plays a critical role in the transport and metabolism of lipids. In addition to its role in maintaining cardiovascular function, ApoE4 is also critically involved in neuronal plasticity, synaptogenesis, aging, and neurodegenerative disorders. Mice deficient in ApoE4 show age-dependent abnormalities in synaptic structure and impaired long term potentiation. Additionally, ApoE4 has a well-documented role in the pathology of Alzheimer’s disease.

ALT Names :

Apolipoprotein E;Apo-E;ApoE4;Apolipoprotein E4

Immunogen :

KLH-conjugated linear peptide corresponding to human ApoE4.

Specificity :

This antibody recognizes ApoE4 but not ApoE3 or ApoE2.

Package Size :

100 µL

Uses :

Western Blotting;Immunohistochemistry;Immunoprecipitation

Storage :

Stable for 1 year at 2-8°C from date of receipt