FIS1 Antibody, Clone 4D1.1 | EMD Millipore MABN391 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

FIS1 Antibody, Clone 4D1.1

catalog :

MABN391

quantity :

100 μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

4D1.1

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunohistochemistry - paraffin section

citations: 1

Published Application/Species/Sample/Dilution	Reference
western blot; mouse; 1:500; fig 6	Bal N, Maurya S, Singh S, Wehrens X, Periasamy M. Increased Reliance on Muscle-based Thermogenesis upon Acute Minimization of Brown Adipose Tissue Function. J Biol Chem. 2016;291:17247-57 pubmed publisher

product information

Catalog Number :

MABN391

Subcategory :

Neuroscience

Product Name :

Anti-FIS1 Antibody, Clone 4D1.1

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

Q9Y3D6

Host Name :

Mouse

Antigen :

TTC11

Clone :

4D1.1

Conjugate :

Purified

Purification Method :

Protein G purified

Isotype :

IgG2bκ

Product Description :

Anti-FIS1 Antibody, Clone 4D1.1

Cross Reactivity :

Human, Rat

Background :

FIS1 or TTC11, or FIS1 homolog (hFis1), or Tetratricopeptide repeat protein 11 (TPR repeat protein 11) or Mitochondrial fission 1 protein is an interesting member of mitochondrial essential proteins. FIS1 is encoded by the nuclear gene FIS1 and is a key player in mitochondrial dynamics. In eukaryotic cells, the shape of mitochondria can be tuned to various physiological conditions by a balance of fusion and fission processes termed mitochondrial dynamics. Mitochondrial dynamics control not only the morphology but also the function of mitochondria, and therefore is crucial in many aspects of a cell's life. Thus there is a dynamic balance between fission and fusion events that can promote health and normal cell growth or when dysfunctional mitochondrial dynamics have been implicated in a variety of human diseases including cancer. Human FIS1 a mitochondrial, outer membrane localized, adaptor protein that is critical to recruiting the cellular machinery needed for mitochondrial fission or fusion. FIS1 is inserted into the mitochondrial outer membrane via a C-terminal transmembrane domain that, along with a short basic segment, is essential for its targeting to the mitochondria. Overexpression of FIS1 in human cells causes mitochondrial fragmentation and aggregation. FIS1 interacts with the dynamin-related GTPase DLP1/DRP1, and along with other adaptor proteins such as MDV1, MFF, and MiD, the dynamin-related proteins form spirals around constricted sites on mitochondria and assist in the fission of it. In addition to mitochondria, FIS1 also mediates peroxisome fission via the interaction with DLP1 as well. EMD-Millipore’s Anti-FIS1 rabbit polyclonal antibody has been tested in western blot on HeLa cell extracts and in immunohistochemistry on human brain tissue sections.

ALT Names :

FIS-1, FIS 1, FIS1 homolog, Mitochondrial fission 1 protein, hFis1, hFis-1hFis 1, Tetratricopeptide repeat protein 11, Short name=TPR repeat protein 11

Immunogen :

GST-tagged recombinant protein corresponding to Human FIS1.

Package Size :

100 μg

Uses :

Western Blotting, Immunohistochemistry (Paraffin)

Storage :

Stable for 1 year at 2-8°C from date of receipt