phospho Tau (Thr181), clone 1E7 | EMD Millipore MABN388 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

phospho Tau (Thr181), clone 1E7

catalog :

MABN388

quantity :

100 μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

antigen modification :

phosphorylated

clone name :

1E7

reactivity :

human, mouse

application :

western blot

product information

Catalog Number :

MABN388

Subcategory :

Neuroscience

Product Name :

Anti-phospho Tau (Thr181), clone 1E7

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P10636

Host Name :

Mouse

Antigen :

MAPT

Conjugate :

Affinity Purified

Purification Method :

Affinity purified

Product Description :

Anti-phospho Tau (Thr181), clone 1E7

Cross Reactivity :

Mouse, Human

Background :

The protein named Tau, or more completely microtubule-associated protein tau, and when associated with disease, neurofibrillary tangle protein, or paired helical filament tau (PHF-tau) and encoded by the human gene MAPT/MAPTL/MTBT1/TAU is an important protein involved in microtubule synthesis and stabilization. The protein is expressed in neurons and it plays a critical role in linking microtubules to the plasma membrane and in microtubule transport and signaling. Tau’s expression is largely confined to the cytosol and axons in neurons and is often highly phosphorylated particularly during cytokinesis in developing neurons and under neurological disease states such as Alzheimer’s. Phosphorylation causes detachment from microtubules and their destabilization. Phosphorylated Tau at Threonine 181, or Tau phsopho-Thr-181, is a phosphorylated form of Tau that is often associated with neuropathological disease. Its levels in CSF increase with age and phosphorylated Tau Thr181 is one of the many biomarkers used to track neurological disease progression. LRRK2 phosphorylates Tau at Thr181, which only occurs when tubulin is associated with Tau otherwise there is no LRRK2-Tau interaction and subsequentTau phosphorylation. The LRRK2 mutant, G2019S, that shows higher PD causes elevated phosphorylation at 181 suggesting a link between the phosphorylation at this site and PD.

ALT Names :

Microtubule-associated protein tau, Neurofibrillary tangle protein, Paired helical filament-tau, F-tau

Immunogen :

Linear peptide corresponding to human Tau phosphorylated at Thr181.

Package Size :

100 μg

Uses :

Western Blotting

Storage :

Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.