APP-C99 Antibody, clone mC99(1-7) | EMD Millipore MABN381 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

APP-C99 Antibody, clone mC99(1-7)

catalog :

MABN381

quantity :

100 µL

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

mC99

reactivity :

human, mouse

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation

product information

Catalog Number :

MABN381

Subcategory :

Neuroscience

Product Name :

Anti-APP-C99 Antibody, clone mC99(1-7)

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P05067

Host Name :

Mouse

Antigen :

APP-C99

Clone :

mC99(1-7)

Conjugate :

Ascites

Product Description :

Anti-APP-C99 Antibody, clone mC99(1-7)

Cross Reactivity :

Human;Mouse

Background :

Amyloid Precursor Protein (APP) is expressed in the brain, kidney, heart, and spleen of fetal tissues; it is induced during neuronal differentiation. The most-substantiated role for APP is in synaptic formation and repair; its expression is upregulated during neuronal differentiation and after neural injury. In adult brain, highest expression of APP is found in the frontal lobe of the cortex. Moderate expression is observed in the cerebellar cortex, the posterior perisylvian cortex-opercular gyri and the temporal associated cortex. Defects in APP are a cause of autosomal dominant Alzheimer's disease (AD). UP on intracerebroventricular injection of this antibody, A beta levels significantly decreased in the brain of APPPS1 mouse model of AD. A related antibody, Cat. No. MABN380, Anti-APP-C99, clone mC99(70-80) was raised against a slightly different region of the same APP-C99 protein.

ALT Names :

Amyloid beta A4 protein;ABPP;APPI;APP;Alzheimer disease amyloid protein;Cerebral vascular amyloid peptide;CVAP;PreA4;Protease nexin-II;PN-II

Immunogen :

Recombinant protein corresponding to Human APP-C99.

Package Size :

100 µL

Uses :

Western Blotting;Immunoprecipitation;Immunocytochemistry;Immunohistochemistry

Storage :

Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.