Alanyl-tRNA synthetase (AARS Antibody), clone M6-P2E5 | EMD Millipore MABN376 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Alanyl-tRNA synthetase (AARS Antibody), clone M6-P2E5

catalog :

MABN376

quantity :

100 μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

P2E5

reactivity :

human, mouse

application :

western blot, immunohistochemistry, immunohistochemistry - paraffin section

product information

Catalog Number :

MABN376

Subcategory :

Neuroscience

Product Name :

Anti-Alanyl-tRNA synthetase (AARS Antibody), clone M6-P2E5

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P49588

Host Name :

Mouse

Antigen :

AARS

Clone :

P2E5

Conjugate :

Purified

Purification Method :

Protein G purified

Isotype :

IgG1κ

Product Description :

Anti-Alanyl-tRNA synthetase (AARS Antibody), clone M6-P2E5

Cross Reactivity :

Human, Mouse

Background :

Alanyl-tRNA synthetase (AARS), also known as Alanine-tRNA ligase, AlaRS, or Renal carcinoma antigen NY-REN-42, and encoded by the gene AARS, is a key transfer RNA synthetase responsible for the attachment of alanine to the tRNA(Ala) for protein translation. Alanine-tRNA ligase also can edit incorrectly charged tRNA(Ala) for proper translation. Alanine-tRNA ligase is a monomer and is localized in the cytoplasm and ubiquitously expressed. Mutations in Alanine-tRNA ligase have been linked to a progressive peripheral nervous disorder called Charcot-Marie Tooth disease. Moreover autoantibodies against aminoacyl tRNA synthetases are some of the most common autoantibodies detected in autoimmune diseases with nearly 25-35% of patients having them, and some of these such as autoantibodies to Alanine-tRNA ligase have also been associated with autologous antibodies in renal carcinoma patients.

ALT Names :

Alanine-tRNA ligase, cytoplasmic, Alanyl-tRNA synthetase, AlaRS, Renal carcinoma antigen NY-REN-42, Anti-Alanyl-tRNA synthetase (AARS), clone M6-P2E5

Immunogen :

Linear peptide corresponding to the C-terminus of human Alanyl-tRNA synthetase (AARS).

Package Size :

100 μg

Uses :

Western Blotting, Immunohistochemistry (Paraffin)

Storage :

Stable for 1 year at 2-8°C from date of receipt