NB thymosin beta (TMSB15A Antibody), Clone 4A6.3 | EMD Millipore MABN358 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

NB thymosin beta (TMSB15A Antibody), Clone 4A6.3

catalog :

MABN358

quantity :

100 μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

4A6.3

reactivity :

human

application :

immunohistochemistry, immunohistochemistry - paraffin section

product information

Catalog Number :

MABN358

Subcategory :

Neuroscience

Product Name :

Anti-NB thymosin beta (TMSB15A Antibody), Clone 4A6.3

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P0CG34

Host Name :

Mouse

Antigen :

TMSB15A

Clone :

4A6.3

Conjugate :

Purified

Purification Method :

Purified by ion-exchange chromatography

Isotype :

IgMκ

Product Description :

Anti-NB thymosin beta (TMSB15A Antibody), Clone 4A6.3

Cross Reactivity :

Human

Background :

TMSB15A protein is a key regulator of the cytoskeleton organization and polymerization, and it thus plays a role in cell migration, proliferation and cancer. TMSB15A does this because TMSB15A binds to and sequesters actin monomers and limits action polymerization. TMSB15A is differentially expressed in many tissues and cancer cell lines. Because of differential expression in certain cancers, for instance in triple negative breast cancer but not colon cancer, TMSB15A is being examined as a histochemical marker for measuring the effectiveness of cancer therapy on cancer. TMSB15A is also important in the nervous system and brain diseases. Notably, TMSB15A expression is increased upon brain stress and surprisingly TMSB15A localization differs depending upon the type of stress used and neuronal cell type. Because of its interaction with actin, TMSB15A is localized to the cytoplasm most of time, however, in the brain and when cells are placed under various stresses, TMSB15A can be translocated to the brain to perform yet unknown functions as well.

ALT Names :

Thymosin beta-15A, NB thymosin beta, Thymosin-like protein 8

Immunogen :

KLH-conjugated linear peptide corresponding to Human TMSB15A.

Package Size :

100 μg

Uses :

Immunohistochemistry (Paraffin)

Storage :

Stable for 1 year at 2-8°C from date of receipt