Transmembrane Prostatic Acid Phosphatase Antibody/TMPAP, clone 3G10.1 | EMD Millipore MABN318 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Transmembrane Prostatic Acid Phosphatase Antibody/TMPAP, clone 3G10.1

catalog :

MABN318

quantity :

100 μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

3G10.1

reactivity :

human

application :

western blot, immunohistochemistry, immunohistochemistry - paraffin section

citations: 1

Reference
Ma H, Zhao H, Liu F, Zhao H, Kong R, Shi L, et al. Heparan sulfate negatively regulates intestinal stem cell proliferation in Drosophila adult midgut. Biol Open. 2019;8: pubmed publisher

product information

Catalog Number :

MABN318

Subcategory :

Neuroscience

Product Name :

Anti-Transmembrane Prostatic Acid Phosphatase Antibody/TMPAP, clone 3G10.1

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P15309

Host Name :

Mouse

Antigen :

ACPP

Clone :

3G10.1

Conjugate :

Purified

Purification Method :

Protein G purified

Isotype :

IgG1κ

Product Description :

Anti-Transmembrane Prostatic Acid Phosphatase Antibody/TMPAP, clone 3G10.1

Cross Reactivity :

Human

Background :

ACPP, also known as Prostatic acid phosphatase, or PAP, 5'-nucleotidase (5'-NT), Ecto-5'-nuclotidase, or Thiamine monophosphatase (TMPase) , and encoded by the gene ACPP, is a non-specific tyrosine phosphatase that has both a secreted form and a cell membrane bound form. ACPP dephosphorylates a diverse number of substrates including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins. ACPP also has lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasma. Additionally, the membrane bound form of ACPP has ecto-5'-nucleotidase activity in dorsal root ganglion (DRG) neurons and acts as a pain suppressor. Finally ACPP can also act as a tumor suppressor of prostate cancer. ACPP isoform 1is secreted and isoform 2 is membrane bound. Isoform 2 appears to shuttle between the cell membrane, lysosomes, and intracellular vesicles. ACPP is expressed in many tissues and is used as a marker in various stages of prostatic cancer diagnostics. Also the enzyme was intensely studied in HIV infection because it can be proteolytically cleaved in seminal fluid to produce several peptides (SEVI peptides) one of which, PAPf39, happens to enhance HIV infection by binding HIV virions and helping to attach them to target cells--interestingly such SEVI peptides are degraded in vitro by EGCG, a compound found in green tea extract.

ALT Names :

Prostatic acid phosphatase, PAP, 5'-nucleotidase, 5'-NT, Ecto-5'-nucleotidase, Thiamine monophosphatase, Transmembrane Prostatic Acid Phosphatase, TMPase, ACPP, TMPAP

Immunogen :

GST-tagged recombinant protein corresponding to human Transmembrane Prostatic Acid Phosphatase/TMPAP.

Package Size :

100 μg

Uses :

Western Blotting, Immunohistochemistry (Paraffin)

Storage :

Stable for 1 year at 2-8°C from date of receipt