CHL1 Antibody, clone BB13.13 | EMD Millipore MABN299 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

CHL1 Antibody, clone BB13.13

catalog :

MABN299

quantity :

100 μg

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

BB13.13

reactivity :

human, mouse

application :

western blot

citations: 1

Reference
Hamilton K, Wang Y, Raefsky S, Berkowitz S, Spangler R, Suire C, et al. Mice lacking the transcriptional regulator Bhlhe40 have enhanced neuronal excitability and impaired synaptic plasticity in the hippocampus. PLoS ONE. 2018;13:e0196223 pubmed publisher

product information

Catalog Number :

MABN299

Subcategory :

Neuroscience

Product Name :

Anti-CHL1 Antibody, clone BB13.13

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P70232

Host Name :

Rat

Antigen :

CHL1

Clone :

BB13.13

Conjugate :

Purified

Isotype :

IgG1κ

Product Description :

Anti-CHL1 Antibody, clone BB13.13

Cross Reactivity :

Human;Mouse

Background :

Close homologue of L1 (CHL1) is a predominantly neural protein, which is highly expressed in the developing nervous system, particularly in neurons and glia of the cerebellum and spinal cord, and in Schwann cells of the peripheral nervous system. In addition to its roles in axon guidance, neuronal growth, and synaptic plasticity, CHL-1 may also regulate the differentiation of neural progenitor cells and the regeneration of nerve tissue. It belongs to the family of L1 adhesion proteins, and produces its effects through the interactions of its multiple domains, which include six immunoglobulin (Ig)-like domains; and over four fibronectin type III (FN)-like repeats. Mice lacking functional CHL-1 show abnormal axonal connectivity and display spatial and cognitive deficits. It has been suggested that the CHL-1 gene (CALL), which has been mapped to chromosome h3p26.1, is required for proper cognitive functioning in humans, and may contribute to “3p-syndrome.”

ALT Names :

Neural cell adhesion molecule L1-like protein;Cell adhesion molecule with homology to L1CAM;Chl1-like protein;Close homolog of L1;Processed neural cell adhesion molecule L1-like protein

Immunogen :

Full length recombinant mouse CHL1 protein

Package Size :

100 μg

Uses :

Western Blotting

Storage :

Stable for 1 year at 2-8°C from date of receipt