IMPDH1 Antibody, clone 4F9.1 | EMD Millipore MABN291 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

IMPDH1 Antibody, clone 4F9.1

catalog :

MABN291

quantity :

100 μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

4F9.1

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry

product information

Catalog Number :

MABN291

Subcategory :

Neuroscience

Product Name :

Anti-IMPDH1 Antibody, clone 4F9.1

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P20839

Host Name :

Mouse

Antigen :

IMPDH1

Clone :

4F9.1

Conjugate :

Purified

Isotype :

IgG2bκ

Product Description :

Anti-IMPDH1 Antibody, clone 4F9.1

Cross Reactivity :

Human;Rat;Mouse

Background :

Inosine-5'-monophosphate dehydrogenase 1 (IMPDH 1) catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), as part of the de novo synthesis of guanine nucleotides. It therefore is crucial in the regulation of cell growth. IMPDH 1 may also have single-stranded nucleic acid-binding activity involving it in RNA and/or DNA metabolism, and is suspected to play a role in the growth progression of some tumors. Defects in IMPDH 1 abnormalities are linked to retinitis pigmentosa type 10 (RP10) and Leber congenital amaurosis type 11 (LCA11). Due to the connection between IMPDH activity and cell proliferation, it has been become a target for cancer and viral chemotherapy and immunosuppressive drugs. The activities of the antitumor drug tiazofurin, the antiviral drug ribavirin, and the immunosuppressive drugs mizoribine and mycophenolic acid (MPA) are attributed to the inhibition of IMPDH. In addition, bacterial and parasitic IMPDH's differ significantly from mammalian enzymes, which make it a suitable target for anti-infective drugs.

ALT Names :

Inosine-5'-monophosphate dehydrogenase 1;IMP dehydrogenase 1;IMPD 1;IMPDH 1;IMPDH-I

Immunogen :

GST-tagged recombinant protein corresponding to human IMPDH1.

Package Size :

100 μg

Uses :

Western Blotting;Immunohistochemistry

Storage :

Stable for 1 year at 2-8°C from date of receipt