amyloid beta peptide (MOAB-2), pan Antibody, clone 6C3 | EMD Millipore MABN254 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

amyloid beta peptide (MOAB-2), pan Antibody, clone 6C3

catalog :

MABN254

quantity :

100 μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

6C3

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section, immunohistochemistry - frozen section, immunohistochemistry - free floating section, other

citations: 7

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry - frozen section; rat; 1:250; loading ...; fig 3d	Muraleva N, Stefanova N, Kolosova N. SkQ1 Suppresses the p38 MAPK Signaling Pathway Involved in Alzheimer's Disease-Like Pathology in OXYS Rats. Antioxidants (Basel). 2020;9: pubmed publisher
immunohistochemistry; mouse; 1:1000; loading ...; fig s3b	Durrant C, Ruscher K, Sheppard O, Coleman M, Ozen I. Beta secretase 1-dependent amyloid precursor protein processing promotes excessive vascular sprouting through NOTCH3 signalling. Cell Death Dis. 2020;11:98 pubmed publisher
other; mouse; 1:1000; fig 3	Hou X, Adeosun S, Zhang Q, Barlow B, Brents M, Zheng B, et al. Differential contributions of ApoE4 and female sex to BACE1 activity and expression mediate Aβ deposition and learning and memory in mouse models of Alzheimer's disease. Front Aging Neurosci. 2015;7:207 pubmed publisher
immunohistochemistry - free floating section; mouse; 1:200	Wang D, Kinoshita Y, Kinoshita C, Uo T, Sopher B, Cudaback E, et al. Loss of endophilin-B1 exacerbates Alzheimer's disease pathology. Brain. 2015;138:2005-19 pubmed publisher
	Bearer E, Manifold Wheeler B, Medina C, Gonzales A, Chaves F, Jacobs R. Alterations of functional circuitry in aging brain and the impact of mutated APP expression. Neurobiol Aging. 2018;70:276-290 pubmed publisher
	Stefanova N, Muraleva N, Maksimova K, Rudnitskaya E, Kiseleva E, Telegina D, et al. An antioxidant specifically targeting mitochondria delays progression of Alzheimer's disease-like pathology. Aging (Albany NY). 2016;8:2713-2733 pubmed publisher
	Khan T, Sen A, Hongpaisan J, Lim C, Nelson T, Alkon D. PKC? deficits in Alzheimer's disease brains and skin fibroblasts. J Alzheimers Dis. 2015;43:491-509 pubmed publisher

product information

Catalog Number :

MABN254

Subcategory :

Neuroscience

Product Name :

Anti-amyloid beta peptide (MOAB-2), pan Antibody, clone 6C3

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P05067

Host Name :

Mouse

Antigen :

amyloid beta peptide (MOAB-2)

Clone :

6C3

Conjugate :

Purified

Product Description :

Anti-amyloid beta peptide (MOAB-2), pan Antibody, clone 6C3

Cross Reactivity :

Human

Background :

Pan-amyloid-beta (1-40) is one of several functional peptides (39 to 43 amino acids in length) formed from proteolytic cleavage of the amyloid-beta precursor protein (APP) by the family of secretase enzymes. Although the APP protein is required for a number of biological functions, including axonal transport, cell adhesion, and transcription, the Ab 1-40 peptide has been studied mostly for its potential to aggregate and form neurite plaques, which may contribute to neurotoxicity, particularly in the context of neurodegenerative disease such as Alzheimer’s. Previous studies have demonstrated that Anti-pan amyloid beta peptide (MOAB2), clone 6C3 detects specifically amyloid-beta, but not APP. Furthermore MOAB2 detects multiple amyloid-beta 40 and amyloid-beta 42 conformations including unaggregated, oligomeric and fibrillar. In a number of immunohistochemical and biochemical analyses, MOAB2 consistently detected intraneuronal amyloid-beta, but not APP, and showed greater specificity to amyloid-beta than 6E10. MOAB2 is therefore suitable for sensitive and specific detection of accumulating amyloid-beta peptides in Alzheimer’s disease models.

ALT Names :

Amyloid beta A4 protein;ABPP;APPI;APP;Alzheimer's disease amyloid protein;cerebral vascular amyloid peptide;CVAP;PreA4;Protease nexin-II;PN-II

Immunogen :

Linear peptide corresponding to human pan amyloid beta peptide (MOAB-2).

Specificity :

This antibody recognizes amyloid-ß and not APP (amyloid precursor protein). Specifically, clone 6C3 recognizes unaggregated, oligomeric, and fibrillar forms of Aß42 and Aß40.

Package Size :

100 μg

Uses :

Western Blotting;Immunohistochemistry (Paraffin);Immunofluorescence;Immunoprecipitation;Dot Blot

Storage :

Stable for 1 year at 2-8°C from date of receipt