Glucagon Antibody, clone 13D11.33 | EMD Millipore MABN238 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Glucagon Antibody, clone 13D11.33

catalog :

MABN238

quantity :

100 μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

13D11.33

reactivity :

human, rat

application :

immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section

product information

Catalog Number :

MABN238

Subcategory :

Neuroscience

Product Name :

Anti-Glucagon Antibody, clone 13D11.33

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P01275

Host Name :

Mouse

Antigen :

Glucagon

Clone :

13D11.33

Conjugate :

Purified

Isotype :

IgG2bκ

Product Description :

Anti-Glucagon Antibody, clone 13D11.33

Cross Reactivity :

Human;Rat

Background :

Glucagon is a hormone that is proteolytically cleaved into at least eight different functional peptides. It is produced by pancreatic cells and it has binding sites in the brain, intestines, and liver, among other tissues. Glucagon is secreted in response to hypoglycemia. Through the combined activation of Gsα- and Gq-coupled transmembrane receptors and their downstream signaling pathways, glucagon stimulates the release of glucose from the liver into the bloodstream. One important mechanism underlying this process is the activation of protein kinase A (PKA). PKA signals result in increased transcription of phosphoenolpyruvate carboxykinase, which encodes the rate-limiting enzyme in the production of glucose from noncarbohydrate substrates. PKA signals may also increase the breakdown of glycogen, and suppress glycolysis. Glucagon may also engage in calcium-dependent signaling via PLC. The importance of glucagon in regulating glucose homeostasis, in conjunction with insulin, is underscored by findings that glucagon and glucagon receptor signaling are disrupted in type II diabetes.

ALT Names :

4030-01F;4031-01F;AB932

Immunogen :

Ovalbumin-conjugated linear peptide corresponding to human Glucagon.

Package Size :

100 μg

Uses :

Immunohistochemistry (Paraffin);Immunofluorescence;ELISA;Multiplexing

Storage :

Stable for 1 year at 2-8°C from date of receipt