phospho TDP-43 (Ser409/Ser410) Antibody, clone 1D3 | EMD Millipore MABN14 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

phospho TDP-43 (Ser409/Ser410) Antibody, clone 1D3

catalog :

MABN14

quantity :

100 μg

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

1D3

reactivity :

human, mouse

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section

citations: 5

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry - paraffin section; human; 1:1000; loading ...; fig 4a	Keith J, Swinkin E, Gao A, Alminawi S, Zhang M, McGoldrick P, et al. Neuropathologic description of CHCHD10 mutated amyotrophic lateral sclerosis. Neurol Genet. 2020;6:e394 pubmed publisher
immunohistochemistry - paraffin section; human; 1:1000; loading ...; fig 6b	Latimer C, Burke B, Liachko N, Currey H, Kilgore M, Gibbons L, et al. Resistance and resilience to Alzheimer's disease pathology are associated with reduced cortical pTau and absence of limbic-predominant age-related TDP-43 encephalopathy in a community-based cohort. Acta Neuropathol Commun. 2019;7:9 pubmed publisher
immunocytochemistry; mouse; fig s2	Kitamura A, Nakayama Y, Shibasaki A, Taki A, Yuno S, Takeda K, et al. Interaction of RNA with a C-terminal fragment of the amyotrophic lateral sclerosis-associated TDP43 reduces cytotoxicity. Sci Rep. 2016;6:19230 pubmed publisher
immunocytochemistry; human; 1:200; fig 4	Zhang T, Baldie G, Periz G, Wang J. RNA-processing protein TDP-43 regulates FOXO-dependent protein quality control in stress response. PLoS Genet. 2014;10:e1004693 pubmed publisher
	Yin P, Guo X, Yang W, Yan S, Yang S, Zhao T, et al. Caspase-4 mediates cytoplasmic accumulation of TDP-43 in the primate brains. Acta Neuropathol. 2019;137:919-937 pubmed publisher

product information

Catalog Number :

MABN14

Subcategory :

Neuroscience

Product Name :

Anti-phospho TDP-43 (Ser409/Ser410) Antibody, clone 1D3

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

Q13148

Host Name :

Rat

Antigen :

phospho TDP-43 (Ser409/Ser410)

Clone :

1D3

Conjugate :

Purified

Isotype :

IgG2aκ

Product Description :

Anti-phospho TDP-43 (Ser409/Ser410) Antibody, clone 1D3

Cross Reactivity :

Human

Background :

TAR DNA-binding protein 43 (TDP-43) belongs to the hnRNP protein family and plays an important role in transcription, pre-mRNA splicing, mRNA stability and mRNA transport. It is involved in splicing of the apolipoprotein A-II and cystic fibrosis transmembrane gene. This protein is highly expressed in the pancreas, placenta, lung, genital tract and spleen. Mutations in TDP-43 have been associated with amyotrophic lateral sclerosis, frontotemporal dementia, Parkinson's disease and Alzheimer's disease.

ALT Names :

TAR DNA binding protein;TAR DNA-binding protein-43;phosphorylated TDP

Immunogen :

Ovalbumin-conjugated linear peptide corresponding to human TDP-43 phosphorylated at Ser409/Ser410.

Specificity :

This antibody recognizes TDP-43 when phosphorylated at Ser409/Ser410.

Package Size :

100 μg

Uses :

Western Blotting;ELISA;Immunohistochemistry

Storage :

Stable for 1 year at 2-8°C from date of receipt