DRD4 Antibody, clone 2B9 | EMD Millipore MABN125 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

DRD4 Antibody, clone 2B9

catalog :

MABN125

quantity :

100 μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

2B9

The same clone is also sold as:

Santa Cruz Biotechnology: sc-136169

reactivity :

human, mouse

application :

western blot, immunocytochemistry, flow cytometry

citations: 1

Published Application/Species/Sample/Dilution	Reference
flow cytometry; human; 1:100	Kim S, Jung J, Dixit D, Rovner R, Zack J, Baldwin G, et al. Cocaine exposure enhances permissiveness of quiescent T cells to HIV infection. J Leukoc Biol. 2013;94:835-43 pubmed publisher

product information

Catalog Number :

MABN125

Subcategory :

Neuroscience

Product Name :

Anti-DRD4 Antibody, clone 2B9

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P21917

Host Name :

Mouse

Antigen :

DRD4

Clone :

2B9

Conjugate :

Purified

Isotype :

IgG1κ

Product Description :

Anti-DRD4 Antibody, clone 2B9

Cross Reactivity :

Mouse;Rat;Human

Background :

Five subtypes of dopamine receptors exist in two subfamilies: two D1-like (D1 and D5) and three D2-like (D2, D3 and D4). As members of the G protein-coupled receptor (GPCR) family, dopamine receptors initiate their biological function by coupling to GTP regulatory proteins (G proteins). D1-like receptors, DRD1 and DRD5, stimulate adenylyl cyclase whereas D2-like receptors, DRD2, DRD3 and DRD4, are coupled to inhibitory G proteins and their stimulation leads to the inhibition of adenylyl cyclase activity, and subsequent respective cellular signaling. All five subtypes have seven transmembrane domains, an extracellular amino terminus, and an intracellular carboxyl terminus. Allelic variants of the D4 dopamine receptor (DRD4) are known characterized risk factors of ADHD. It is reported that hypoxia enhances DRD4 promoter activity by several fold. It is also thought that dopamine receptors such as DRD4 are involved in neuroexcitation and in a variety of other neurological and psychiatric disorders.

ALT Names :

D(4) dopamine receptor;D(2C) dopamine receptor;Dopamine D4 receptor

Immunogen :

Linear peptide corresponding to human DRD4.

Package Size :

100 μg

Uses :

Western Blotting;Immunocytochemistry

Storage :

Stable for 1 year at 2-8°C from date of receipt