Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

antibody

Anti-PSMA7, clone EPR5836, Rabbit Monoclonal Antibody

MABN1122

100 µL

monoclonal

rabbit

nonconjugated

EPR5836

The same clone is also sold as:

• Abcam: ab133502

western blot, immunohistochemistry

Neuroscience

Anti-PSMA7, clone EPR5836, Rabbit Monoclonal Antibody

Antibodies

Monoclonal Antibody

O14818

Rabbit

PSMA7

EPR5836

Unpurified

Unpurified

IgG

Anti-PSMA7, clone EPR5836, Rabbit Monoclonal Antibody

Human

PSMA (prostate specific membrane antigen) is a type II, integral membrane glycoprotein, composed of a 19 amino acid intracellular domain containing the N-terminus, a 24 amino acid transmembrane region, and a 707 amino acid extracellular C-terminal domain. The PSMA gene has been cloned and sequenced, and has been localized to chromosome 11q. PSMA is highly expressed in prostate secretory-acinar epithelium, in some benign extraprostatic epithelial cells from breast, duodenum, and kidney tissues, and in prostate cancer. Recently, evidence of limited and specific endothelial PSMA expression has been discovered: the neovasculature of a wide variety of malignant neoplasms (lung, colon, breast, etc.) demonstrates PSMA expression. This finding suggests that PSMA may be an effective target for monoclonal antibody-based anti-neovasculature therapy. PSMA has also been identified in the human nervous system. Based on activity, immunoreactivity, and mRNA sequence comparison with one form of NAALADase, a neuropeptide that may modulate glutaminergic transmission in the nervous system, PSMA was found to be indistinguishable from NAALADase derived from human cerebellar cell isolates. Therefore, the form of NAALADase also known as PSMA is expressed in brain, where it makes up a significant fraction of brain NAALADase activity.

Proteasome subunit alpha type-7, Proteasome subunit RC6-1, Proteasome subunit XAPC7

Synthetic peptide corresponding to human PSMA7.

100 µL

Western Blotting, Immunohistochemistry

Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.