Anti-Huntingtin Protein (Htt), clone EPR5526, Rabbit Monoclonal Antibody | EMD Millipore MABN1105 product information

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Anti-Huntingtin Protein (Htt), clone EPR5526, Rabbit Monoclonal Antibody

catalog :

MABN1105

quantity :

100 µL

clonality :

monoclonal

host :

rabbit

conjugate :

nonconjugated

clone name :

EPR5526

reactivity :

human

application :

western blot, immunohistochemistry, immunocytochemistry

more info or order :

EMD Millipore product webpage

product information

Catalog Number :

MABN1105

Subcategory :

Neuroscience

Product Name :

Anti-Huntingtin Protein (Htt), clone EPR5526, Rabbit Monoclonal Antibody

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P42858

Host Name :

Rabbit

Antigen :

HTT

Clone :

EPR5526

Conjugate :

Unpurified

Purification Method :

Unpurified

Isotype :

IgG

Product Description :

Anti-Huntingtin Protein (Htt), clone EPR5526, Rabbit Monoclonal Antibody

Cross Reactivity :

Human

Background :

Huntington disease (HD) is a hereditary, progressive, neurodegenerative ailment characterized by personality changes, motor impairment and subcortical dementia. The molecular basis of the disease involves the expansion of the trinucleotide CAG, coding for polyglutamine in the first exon of a chromosome four gene (4p16.3), which normally produces a widely expressed 3136 a.a. (~350 kDa) protein Huntingtin with unclear function. The protein is found in the perinuclear region along with microtubules, and in the centrosomal region along with gamma-tubulin. Huntingtin is necessary for neuronal survival and is involved in synaptic vesicle trafficking, microtubule binding and may also have a role in apoptosis. In the HD condition, neuronal cells with the mutant form of huntingtin possess intranuclear aggregations of the N-terminal fragment, causing damaging inclusions in perinuclear locations and striatal neuron cell death. Huntingtin is known to interact with GAPDH, HAP-1, SP1 and TAFII130.

ALT Names :

Huntingtin, Huntington disease protein, HD protein

Immunogen :

Synthetic peptide corresponding to the N-terminus of human Huntingtin Protein (Htt).

Package Size :

100 µL

Uses :

Western Blotting, Immunohistochemistry, Immunocytochemistry

Storage :

Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.

more info or order :

EMD Millipore product webpage