GLUR2 pS880 (Clone 022.19.5) Antibody | EMD Millipore MABN103 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

GLUR2 pS880 (Clone 022.19.5) Antibody

catalog :

MABN103

quantity :

100 μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

022.19.5

reactivity :

mouse, rat

application :

western blot

citations: 1

Published Application/Species/Sample/Dilution	Reference
western blot; mouse; fig 4	Mayanagi T, Yasuda H, Sobue K. PSD-Zip70 Deficiency Causes Prefrontal Hypofunction Associated with Glutamatergic Synapse Maturation Defects by Dysregulation of Rap2 Activity. J Neurosci. 2015;35:14327-40 pubmed publisher

product information

Catalog Number :

MABN103

Subcategory :

Neuroscience

Product Name :

Anti-GLUR2 pS880 (Clone 022.19.5) Antibody

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P19491

Host Name :

Mouse

Antigen :

GLUR2 pS880 (Clone 022.19.5)

Clone :

022.19.5

Conjugate :

Purified

Isotype :

IgG2aκ

Product Description :

Anti-GLUR2 pS880 (Clone 022.19.5) Antibody

Cross Reactivity :

Rat

Background :

Glutamate receptors (GluRs) can be categorized as ionotropic or metabotropic and subcatergorized by their agonist preferences (NMDA, AMPA or Kainic acid). There are four types of AMPA selective GluR subunits (GluR1, GluR2, GluR3 and GluR4). Tetrameric or pentameric combinations of different subunits contributes to the functional diversity of AMPA receptors. In general, AMPA receptors mediate fast synaptic current at most excitatory synapses, with stoichiometry characterized by subtype composition. Although subunit composition of AMPA receptors varies, they must contain at least one edited GluR2 subunit to be calcium impermeable. Ser880 has been identified as the protein kinase C (PKC) phosphorylation site within the C-terminal region of GluR2 and has been shown to differentially regulate the interaction of the PDZ domain-containing proteins GRIP1 and PICK 1. In addition, PKC phosphorylation of GluR2 Ser880 appears to be a critical event in the induction of cerebellar long term depression (LTD).

ALT Names :

Glutamate receptor 2;GluR-2;AMPA-selective glutamate receptor 2;GluR-B;GluR-K2;Glutamate receptor ionotropic, AMPA 2;GluA2

Immunogen :

KLH-conjugated linear peptide corresponding to rat GluR2 phosphorylated at Ser880.

Specificity :

This antibody recognizes GluR2 phosphorylated at Ser880.

Package Size :

100 μg

Uses :

Western Blotting

Storage :

Stable for 1 year at 2-8°C from date of receipt