Amyloid β Antibody, clone W0-2 | EMD Millipore MABN10 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Amyloid β Antibody, clone W0-2

catalog :

MABN10

quantity :

50 μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

WO2

The same clone is also sold as:

Absolute Antibody: Ab00239-23.0, Ab00239-2.0

reactivity :

human, mouse

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section, immunohistochemistry - free floating section

citations: 15

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry - paraffin section; human; 1:800; loading ...; fig 1e	Kirabali T, Rigotti S, Siccoli A, Liebsch F, Shobo A, Hock C, et al. The amyloid-β degradation intermediate Aβ34 is pericyte-associated and reduced in brain capillaries of patients with Alzheimer's disease. Acta Neuropathol Commun. 2019;7:194 pubmed publisher
western blot; human; loading ...; fig 1c	Tan J, Gleeson P. The trans-Golgi network is a major site for α-secretase processing of amyloid precursor protein in primary neurons. J Biol Chem. 2019;294:1618-1631 pubmed publisher
western blot; human; loading ...; fig 4f	Liebsch F, Aurousseau M, Bethge T, McGuire H, Scolari S, Herrmann A, et al. Full-length cellular ?-secretase has a trimeric subunit stoichiometry, and its sulfur-rich transmembrane interaction site modulates cytosolic copper compartmentalization. J Biol Chem. 2017;292:13258-13270 pubmed publisher
western blot; human; loading ...; fig 3b	Tapia Rojas C, Burgos P, Inestrosa N. Inhibition of Wnt signaling induces amyloidogenic processing of amyloid precursor protein and the production and aggregation of Amyloid-? (A?)42 peptides. J Neurochem. 2016;139:1175-1191 pubmed publisher
western blot; mouse; 1:300; fig 2	Tiwari S, Mizuno K, Ghosh A, Aziz W, Troakes C, Daoud J, et al. Alzheimer-related decrease in CYFIP2 links amyloid production to tau hyperphosphorylation and memory loss. Brain. 2016;139:2751-2765 pubmed
immunocytochemistry; mouse; fig 6	Bhattacharjee S, Zhao Y, Dua P, Rogaev E, Lukiw W. microRNA-34a-Mediated Down-Regulation of the Microglial-Enriched Triggering Receptor and Phagocytosis-Sensor TREM2 in Age-Related Macular Degeneration. PLoS ONE. 2016;11:e0150211 pubmed publisher
immunohistochemistry; mouse; fig 2e	Tapia Rojas C, Lindsay C, Montecinos Oliva C, Arrázola M, Retamales R, Bunout D, et al. Is L-methionine a trigger factor for Alzheimer's-like neurodegeneration?: Changes in AÎ² oligomers, tau phosphorylation, synaptic proteins, Wnt signaling and behavioral impairment in wild-type mice. Mol Neurodegener. 2015;10:62 pubmed publisher
western blot; human; fig 1g	Parsi S, Smith P, Goupil C, Dorval V, HÃ©bert S. Preclinical Evaluation of miR-15/107 Family Members as Multifactorial Drug Targets for Alzheimer's Disease. Mol Ther Nucleic Acids. 2015;4:e256 pubmed publisher
western blot; mouse; 1:2000	Leinenga G, GÃ¶tz J. Scanning ultrasound removes amyloid-Î² and restores memory in an Alzheimer's disease mouse model. Sci Transl Med. 2015;7:278ra33 pubmed publisher
western blot; human; loading ...; fig 4b	Sutinen E, Korolainen M, HÃ¤yrinen J, Alafuzoff I, Petratos S, Salminen A, et al. Interleukin-18 alters protein expressions of neurodegenerative diseases-linked proteins in human SH-SY5Y neuron-like cells. Front Cell Neurosci. 2014;8:214 pubmed publisher
immunohistochemistry - free floating section; human; fig 1	Stancu I, Ris L, Vasconcelos B, Marinangeli C, Goeminne L, Laporte V, et al. Tauopathy contributes to synaptic and cognitive deficits in a murine model for Alzheimer's disease. FASEB J. 2014;28:2620-31 pubmed publisher
	Tan J, Fourrière L, Wang J, Perez F, Boncompain G, Gleeson P. Distinct anterograde trafficking pathways of BACE1 and amyloid precursor protein from the TGN and the regulation of amyloid-β production. Mol Biol Cell. 2020;31:27-44 pubmed publisher
	Wong E, Liao G, Chang J, Xu P, Li Y, Greengard P. GSAP modulates γ-secretase specificity by inducing conformational change in PS1. Proc Natl Acad Sci U S A. 2019;116:6385-6390 pubmed publisher
	Vargas L, Leal N, Estrada L, González A, Serrano F, Araya K, et al. EphA4 activation of c-Abl mediates synaptic loss and LTP blockade caused by amyloid-β oligomers. PLoS ONE. 2014;9:e92309 pubmed publisher
	Semar S, Klotz M, Letiembre M, Van Ginneken C, Braun A, Jost V, et al. Changes of the enteric nervous system in amyloid-? protein precursor transgenic mice correlate with disease progression. J Alzheimers Dis. 2013;36:7-20 pubmed publisher

product information

Catalog Number :

MABN10

Subcategory :

Neuroscience

Product Name :

Anti-Amyloid β Antibody, clone W0-2

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P05067

Host Name :

Mouse

Antigen :

Amyloid β

Clone :

WO2

Conjugate :

Purified

Isotype :

IgG2aκ

Product Description :

Anti-Amyloid β Antibody, clone W0-2

Cross Reactivity :

Mouse;Human

Background :

The cerebral and vascular plaques associated with Alzheimer's disease (AD) are mainly composed of amyloid beta peptides (Aβ). Aβ is derived from cleavage of the amyloid precursor protein (APP) and varies in length from 39 to 43 amino acids. Aβ [1-40], Aβ [1-42], and Aβ [1-43] peptides result from cleavage of APP after residues 40, 42, and 43, respectively. The cleavage takes place by gamma-secretase during the last APP processing step. Aβ [1-40], [1-42] and [1-43] peptides are major constituents of the plaques and tangles that occur in AD. These Amyloid beta antibodies and peptides have been developed as tools for elucidating the biology of AD.

ALT Names :

Alzheimer disease;Alzheimer disease amyloid protein;Cerebral vascular amyloid peptide;Protease nexin-II;amyloid beta (A4) precursor protein;amyloid beta A4 protein;amyloid beta precursor protein;beta-amyloid peptide;human mRNA for amyloid A4 precursor of Alzheimer's disease;peptidase nexin-II

Immunogen :

Human Amyloid β peptide

Specificity :

This antibody recognizes amino acid residues 4-10 of human Amyloid β.

Package Size :

50 μg

Uses :

Western Blotting;Immunohistochemistry (Paraffin);ELISA

Storage :

Stable for 1 year at 2-8°C from date of receipt