ROR gamma T Antibody, clone 6F3.1 | EMD Millipore MABF81 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

ROR gamma T Antibody, clone 6F3.1

catalog :

MABF81

quantity :

100 μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

6F3.1

reactivity :

human, mouse

application :

western blot, immunohistochemistry, immunoprecipitation, immunohistochemistry - paraffin section

citations: 4

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry - paraffin section; human; loading ...; fig ex5a	Ardain A, Domingo Gonzalez R, Das S, Kazer S, Howard N, Singh A, et al. Group 3 innate lymphoid cells mediate early protective immunity against tuberculosis. Nature. 2019;: pubmed publisher
immunoprecipitation; mouse; loading ...; fig 2d	Chuang H, Tsai C, Hsueh C, Tan T. GLK-IKKβ signaling induces dimerization and translocation of the AhR-RORγt complex in IL-17A induction and autoimmune disease. Sci Adv. 2018;4:eaat5401 pubmed publisher
western blot; human; loading ...; fig 2d	Oh T, Wang S, Acharya B, Goode J, Graham J, Clarke C, et al. The Nuclear Receptor, ROR?, Regulates Pathways Necessary for Breast Cancer Metastasis. EBioMedicine. 2016;6:59-72 pubmed publisher
	Li Z, Hodgkinson T, Gothard E, Boroumand S, Lamb R, Cummins I, et al. Epidermal Notch1 recruits RORγ(+) group 3 innate lymphoid cells to orchestrate normal skin repair. Nat Commun. 2016;7:11394 pubmed publisher

product information

Catalog Number :

MABF81

Subcategory :

Inflammation & Immunology

Product Name :

Anti-ROR gamma T Antibody, clone 6F3.1

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P51449

Host Name :

Mouse

Antigen :

ROR gamma T

Clone :

6F3.1

Conjugate :

Purified

Isotype :

IgG2aκ

Product Description :

Anti-ROR gamma T Antibody, clone 6F3.1

Cross Reactivity :

Human

Background :

Retinoid-related orphan receptor-gamma t (RORγT) is one of two RORγ isoforms belonging to the nuclear hormone receptor family and contains a single nuclear receptor DNA-binding domain. RORγT is a negative regulator of TNFDF6/FASL expression and T-cell production of IL2. The upregulation of RORγT is a requirement for TH17 cell differentiation. Inhibition of RORγT is induced by TGF-β’s interaction with Foxp3. Expression is observed mainly in immature thymocytes, and, during fetal development, is found exclusively in lymphoid-inducer (LTi) cells.

ALT Names :

Nuclear receptor ROR-gamma;Nuclear receptor RZR-gamma;Nuclear receptor subfamily 1 group F member 3;Retinoid-related orphan receptor-gamma

Immunogen :

GST-tagged recombinant protein corresponding to human ROR gamma T.

Package Size :

100 μg

Uses :

Western Blotting;Immunohistochemistry

Storage :

Stable for 1 year at 2-8°C from date of receipt