CD4 Antibody (human), APC, clone OKT4 | EMD Millipore MABF572 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

CD4 Antibody (human), APC, clone OKT4

catalog :

MABF572

quantity :

25 tests

clonality :

monoclonal

host :

mouse

conjugate :

APC

clone name :

OKT4

The same clone is also sold as:

Caprico Biotechnologies: 100425, 100401, 100445, 100465, 100415
Bio X Cell: BE0003-2-25MG, BE0003-2-100MG, BE0003-2-5MG, BE0003-2-50MG, BE0003-2-1MG
MyBioSource: MBS9200524
Boster: FC00344-PE, FC00344, FC00344-APC
Rockland Immunochemicals: 200-308-N18, 200-302-N18, 200-326-N18
Abnova: MAB12207, MAB12206
Tonbo Biosciences: 70-0048
BioLegend: 317412, 317441, 317407, 317443, 317431, 317410, 317402, 317406, 317445, 317448, 317415, 317451, 317440, 317411, 317426, 317401, 317442, 317409, 317418, 317423, 317427, 317447, 317408, 317453, 317434, 317425, 317419, 317413, 317444, 317414, 317433, 317437, 317436, 317429, 317439, 317435, 317432, 317420, 317405, 317454, 317424, 317416, 317428, 317422, 317438, 317450, 317417
US Biological: 030850-Biotin, 030850-APC, 030850-AP, 030849, 030850
LifeSpan Biosciences: LS-C41126, LS-C250183, LS-C250180

reactivity :

human

application :

western blot, immunocytochemistry, immunoprecipitation, flow cytometry

product information

Catalog Number :

MABF572

Subcategory :

Inflammation & Immunology

Product Name :

Anti-CD4 Antibody (human), APC, clone OKT4

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P01730

Host Name :

Mouse

Antigen :

CD4

Clone :

OKT4

Conjugate :

APC

Purification Method :

Size Exclusion Chromatography

Isotype :

IgG2bκ

Product Description :

Anti-CD4 Antibody (human), APC, clone OKT4

Cross Reactivity :

Human

Background :

The OKT4 antibody reacts with human CD4, a 59 kDa protein which acts as a co-receptor for the T cell receptor (TCR) in its interaction with MHC Class II molecules on antigen-presenting cells. The extracellular domain of CD4 binds to the beta-2 domain of MHC Class II, while its cytoplasmic tail provides a binding site for the tyrosine kinase lck, facilitating the signaling cascade that initiates T cell activation. CD4, and co-receptors CCR5 and CXCR4, may also be utilized by HIV-1 to enter T cells. Human CD4 is typically expressed on thymocytes, some mature T cell populations such as Th17 and T regulatory (Treg) cells, as well as on dendritic cells. The OKT4 antibody is widely used as a phenotypic marker for CD4 expression. It is cross-reactive with CD4 in several non-human species, including Chimpanzee, Cynomolgus and Rhesus. This antibody recognizes a different epitope, and thus does not block binding of, the alternative Anti-Human CD4 antibody clone RPA-T4 (Reinherz EL, et al. 1979. Proc. Natl. Acad. Sci. 76:4061-4065).

ALT Names :

T-cell surface glycoprotein CD4, T-cell surface antigen T4/Leu-3, CD antigen CD4

Immunogen :

Immunogen information for this antibody is proprietary information.

Package Size :

25 tests

Uses :

Western Blotting, Immunoprecipitation, Immunocytochemistry, Immunofluorescence, Flow Cytometry

Storage :

It is recommended to store the product undiluted at 2-8°C and protected from prolonged exposure to light. Do not freeze.