CD25 Antibody (mouse), APC, clone PC61.5 | EMD Millipore MABF548 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

CD25 Antibody (mouse), APC, clone PC61.5

catalog :

MABF548

quantity :

25 µg

clonality :

monoclonal

host :

rat

conjugate :

APC

clone name :

PC61.5

The same clone is also sold as:

Abcam: ab210333, ab210334, ab210330
Tonbo Biosciences: 70-0251
Abnova: MAB10161, MAB10160
Exbio: 1A-614-C025, 11-614-C100, 1A-614-C100, 12-614-C100, 1F-614-C100, 1P-614-C100
Invitrogen: 63-0251-82, 62-0251-82, 36-0251-85, 48-0251-80, 51-0251-80, 79-0251-80, 78-0251-80, 51-0251-82, 47-0251-82, 62-0251-80, 13-0251-81, 56-0251-80, 79-0251-82, 505-0251-80, 13-0251-86, 64-0251-80, 64-0251-82, 16-0251-85, 58-0251-82, 53-0251-82, 35-0251-80, 16-0251-050, 45-0251-82, 13-0251-82, 13-0251-85, 14-0251-85, 11-0251-80, 61-0251-80, 47-0251-80, 12-0251-82, 12-0251-83, 17-0251-82, 53-0251-80, 606-0251-82, 67-0251-80, 67-0251-82, 78-0251-82, 48-0251-82, 11-0251-82, 46-0251-82, 63-0251-80, 25-0251-81, 17-0251-81, 14-0251-81, 606-0251-80, 61-0251-82, 14-0251-86, 58-0251-80, 12-0251-81, 45-0251-80, 35-0251-82, 15-0251-82, 56-0251-82, 16-0251-025, 16-0251-38, 25-0251-82, 69-0251-82, 505-0251-82, 69-0251-80

reactivity :

mouse

application :

immunohistochemistry, immunoprecipitation, flow cytometry

product information

Catalog Number :

MABF548

Subcategory :

Inflammation & Immunology

Product Name :

Anti-CD25 Antibody (mouse), APC, clone PC61.5

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P01590

Host Name :

Rat

Antigen :

Il2ra

Clone :

PC61.5

Conjugate :

APC

Purification Method :

Size Exclusion Chromatography

Isotype :

IgG1λ

Product Description :

Anti-CD25 Antibody (mouse), APC, clone PC61.5

Cross Reactivity :

Mouse

Background :

The PC61.5 antibody is specific for mouse CD25, a 55 kDa surface protein also known as the Interleukin-2 Receptor alpha chain, or IL-2R alpha. CD25 may bind IL-2 by itself, although with low affinity and without induction of cell signaling. CD25 is also expressed within a high-affinity complex, along with the IL-2R beta chain (CD122) and the common gamma chain (CD132), to form a signaling receptor complex. Expression of CD25 varies during developmental stages of T and B cells, is induced on activated mature T and B cells, and is present on subsets of dendritic cells. CD25 signaling as part of the IL-2 receptor complex triggers T cell activation and proliferation, as well as modulating the differentiation and function of Th17 cells, T regulatory (Treg) cells, and dendritic cells. The PC61.5 antibody is used as a marker for T cells, B cells and dendritic cell subsets. Expression of CD25, CD4 and the transcription factor Foxp3 is regarded as a phenotypic signature for Treg cells. As such, this antibody is widely used for depletion of Treg cells in vivo, as well as to distinguish Treg cells from naïve or conventional T cells which are CD25-.

ALT Names :

Interleukin-2 receptor subunit alpha, IL-2 receptor subunit alpha, IL-2-RA, IL-2R subunit alpha, IL2-RA, p55, CD25

Immunogen :

Immunogen information for this antibody is proprietary information.

Package Size :

25 µg

Uses :

Immunoprecipitation, Immunohistochemistry, Flow Cytometry

Storage :

It is recommended to store the product undiluted at 2-8°C and protected from prolonged exposure to light. Do not freeze.