CD152 (CTLA-4) Antibody (mouse), APC, clone UC10-4F10-11 | EMD Millipore MABF545 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

CD152 (CTLA-4) Antibody (mouse), APC, clone UC10-4F10-11

catalog :

MABF545

quantity :

25 μg

clonality :

monoclonal

host :

hamsters

conjugate :

APC

clone name :

UC10-4F10-11

The same clone is also sold as:

BD Biosciences: 553719, 553718, 561718, 553720
ichorbio: ICH1085
Tonbo Biosciences: 70-1522
Bio X Cell: BE0032-1MG, BE0032-25MG, BP0032-100MG, BP0032-25MG, BP0032-50MG, BP0032-5MG, BE0032-50MG, BE0032-5MG, BE0032-100MG

reactivity :

mouse

application :

flow cytometry

product information

Catalog Number :

MABF545

Subcategory :

Inflammation & Immunology

Product Name :

Anti-CD152 (CTLA-4) Antibody (mouse), APC, clone UC10-4F10-11

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P09793

Host Name :

Armenian Hamster

Antigen :

Ctla4

Clone :

UC10-4F10-11

Conjugate :

APC

Purification Method :

Size Exclusion Chromatography

Isotype :

IgG

Product Description :

Anti-CD152 (CTLA-4) Antibody (mouse), APC, clone UC10-4F10-11

Cross Reactivity :

Mouse

Background :

The UC10-4F10-11 antibody is specific for mouse CD152, commonly known as CTLA-4, a 33-37 kDa protein expressed as a homodimer on the surface of activated T and B cells, and on thymocytes. CTLA-4 is structurally similar, yet functionally disparate, to the T cell co-stimulatory molecule CD28. Both CTLA-4 and CD28 interact with the co-stimulatory molecules CD80 (B7-1) and CD86 (B7-2) on antigen-presenting cells, with CTLA-4 displaying a higher avidity than CD28. While CD28 typically delivers a potent co-stimulatory signal in support of T cell activation, CTLA-4 appears to act as a negative regulator of T cell activation and may contribute to the suppressor function of Treg cells.CTLA-4 proteins may be initially sequestered within Golgi vesicles, from which they can be rapidly transferred to and from the cell surface, a mechanism by which Treg cells can selectively impart suppressive functions. The UC10-4F10-11 antibody may be used for flow cytometric analysis of CTLA-4 expression.

ALT Names :

Cytotoxic T-lymphocyte protein 4, Cytotoxic T-lymphocyte-associated antigen 4, CTLA-4, CD152

Immunogen :

Immunogen information for this antibody is proprietary information.

Package Size :

25 μg

Uses :

Flow Cytometry

Storage :

It is recommended to store the product undiluted at 2-8°C and protected from prolonged exposure to light. Do not freeze.