CD127 (IL-7Ra) Antibody (human), PE, clone A7R34 | EMD Millipore MABF543 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

CD127 (IL-7Ra) Antibody (human), PE, clone A7R34

catalog :

MABF543

quantity :

25 tests

clonality :

monoclonal

host :

mouse

conjugate :

clone name :

R34-34

The same clone is also sold as:

Enzo Life Sciences: ENZ-ABS253-0100, ENZ-ABS252-0100, ENZ-ABS250-0100, ENZ-ABS249-0100, ENZ-ABS251-0100
OriGene: DDX0700P-100, DDX0700A488-100, DDX0700A647-100, DDX0700A546-100
Novus Biologicals: DDX0700P-100
Beckman Coulter: A71116, A64618, A64617

reactivity :

human

application :

flow cytometry

product information

Catalog Number :

MABF543

Subcategory :

Inflammation & Immunology

Product Name :

Anti-CD127 (IL-7Ra) Antibody (human), PE, clone A7R34

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P16871

Host Name :

Mouse

Antigen :

IL7R

Clone :

R34-34

Conjugate :

Purification Method :

Size Exclusion Chromatography

Isotype :

IgG1κ

Product Description :

Anti-CD127 (IL-7Ra) Antibody (human), PE, clone A7R34

Cross Reactivity :

Human

Background :

The R34-34 antibody is specific for human CD127, a cell surface protein also known as the Interleukin-7 Receptor alpha chain, or IL-7R alpha. CD127 is typically expressed at the cell surface as a heterodimer with the common gamma chain (CD132). This complex acts as the functional receptor for IL-7, a cytokine important in T and B cell development, and in mature T cell homeostasis. A second cytokine known as Thymic Stromal Lymphopoietin (TSLP) also binds to a receptor complex of CD127 and the TSLPR chain to trigger activation of dendritic cells, and is involved in B cell development, allergy and autoimmunity. The R34-34 antibody may be used as a phenotypic marker for CD127 on immature B cells, on subsets of thymocytes which are double negative (CD4-CD8- ) or single positive (CD4+ or CD8+), and at low levels on mature, peripheral T cells. CD127 is a key marker, when used in combination with CD4 and CD25, to distinguish Treg and effector/memory Treg populations known as T(REM), whereas certain populations of Foxp3+ /CD25+ T cells lacking CD127 have been associated with impaired suppressive function (Bikker et al. 2012. Rheumatology, 51: 996-1005)

ALT Names :

Interleukin-7 receptor subunit alpha, IL-7 receptor subunit alpha, IL-7R subunit alpha, IL-7R-alpha, IL-7RA, CDw127, CD antigen CD127

Immunogen :

Immunogen information for this antibody is proprietary information.

Package Size :

25 tests

Uses :

Flow Cytometry

Storage :

It is recommended to store the product undiluted at 2-8°C and protected from prolonged exposure to light. Do not freeze.