CD117 (c-Kit) Antibody (mouse), PE, clone ACK2 | EMD Millipore MABF511 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

CD117 (c-Kit) Antibody (mouse), PE, clone ACK2

catalog :

MABF511

quantity :

25 μg

clonality :

monoclonal

host :

rat

conjugate :

clone name :

ACK2

The same clone is also sold as:

Bio X Cell: BE0293-100MG, BE0293-5MG, BE0293-25MG, BE0293-1MG, BE0293-50MG
Invitrogen: 16-1172-85, 17-1172-82, 47-1172-82, 14-1172-85, 67-1172-80, 62-1172-80, 16-1172-050, 62-1172-82, 14-1172-81, 16-1172-025, 12-1172-82, 47-1172-80, 61-1172-80, 56-1172-80, 17-1172-81, 46-1172-80, 16-1172-82, 46-1172-82, 12-1172-83, 14-1172-82, 61-1172-82, 17-1172-83, 56-1172-82, 67-1172-82, 25-1172-82, 16-1172-81, 16-1172-38
BioLegend: 135108, 135118, 135138, 135140, 135136, 135132, 135133, 135115, 135124, 135139, 135102, 135112, 135129, 135120, 135114, 135135, 135101, 135107, 135121, 135125, 135106, 135119, 135128, 135131, 135105, 135123, 135111, 135122, 135134, 135127
LifeSpan Biosciences: LS-C107133
Abnova: MAB10952
Novus Biologicals: NBP1-43359-0.1mg
OriGene: TA320402

reactivity :

mouse

application :

immunohistochemistry, immunocytochemistry, flow cytometry

product information

Catalog Number :

MABF511

Subcategory :

Inflammation & Immunology

Product Name :

Anti-CD117 (c-Kit) Antibody (mouse), PE, clone ACK2

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P05532

Host Name :

Rat

Antigen :

Kit

Clone :

ACK2

Conjugate :

Purification Method :

Size Exclusion Chromatography

Isotype :

IgG2bκ

Product Description :

Anti-CD117 (c-Kit) Antibody (mouse), PE, clone ACK2

Cross Reactivity :

Mouse

Background :

The ACK2 antibody is specific for CD117, also called c-Kit, a 145 kDa cytokine receptor important in the development of hematopoietic stem cells, in oogenesis, and for functional activity of immune cells such as NK and mast cells. c-Kit binds to a ligand known as stem cell factor (SCF), or alternatively as mast cell growth factor. Ligand binding promotes the activation (dimerization) and subsequent tyrosine kinase activity of the c-Kit receptor and triggers key survival, expansion and maturation signals during hematopoietic progenitor cell development. Conversely, shedding of extracellular domain of c-Kit receptor is reported to induce inactivation or apoptosis within these cells. The survival signaling activity of c-Kit confers a proto-oncogenic attribute to the receptor, as overexpression or mutations in this protein are associated with tumor development.The ACK2 antibody is widely utilized as a marker to identify hematopoietic progenitors, and to neutralize receptor-ligand binding in vitro and in vivo. In addition, the antibody is reported to be cross-reactive with rat c-Kit and is extensively published for use in this species.

ALT Names :

Mast/stem cell growth factor receptor Kit, SCFR, Proto-oncogene c-Kit, Tyrosine-protein kinase Kit, CD117

Immunogen :

Immunogen information for this antibody is proprietary information.

Package Size :

25 μg

Uses :

Immunohistochemistry, Immunocytochemistry, Flow Cytometry

Storage :

It is recommended to store the product undiluted at 2-8°C and protected from prolonged exposure to light. Do not freeze.