Foxp3 Antibody (mouse), PE, clone 3G3 | EMD Millipore MABF464 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Foxp3 Antibody (mouse), PE, clone 3G3

catalog :

MABF464

quantity :

100 μg

clonality :

monoclonal

host :

mouse

conjugate :

clone name :

3G3

The same clone is also sold as:

Abnova: MAB0107, MAB9852
Tonbo Biosciences: 35-5773
MilliporeSigma: SAB4700611, SAB4700610
Novus Biologicals: NB100-56582, NBP2-33297
OriGene: AM12131PU-N, TA336416
Exbio: 11-601-C025, 1P-601-C025, 1P-601-C100, 11-601-C100, A6-601-C100, 1A-601-C100, 1A-601-C025, A4-601-C025, A4-601-C100, A6-601-C025
Invitrogen: A18690, MA5-16222, MA1-41628, A18662, MA1-10332, MA5-18160, MA5-18159, MA5-16224
LifeSpan Biosciences: LS-C47269, LS-C368324
Santa Cruz Biotechnology: sc-52899

reactivity :

mouse

application :

flow cytometry

product information

Catalog Number :

MABF464

Subcategory :

Inflammation & Immunology

Product Name :

Anti-Foxp3 Antibody (mouse), PE, clone 3G3

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

Q99JB6

Host Name :

Mouse

Antigen :

PFoxp3

Clone :

3G3

Conjugate :

Purification Method :

Size Exclusion Chromatography

Isotype :

IgG1κ

Product Description :

Anti-Foxp3 Antibody (mouse), PE, clone 3G3

Cross Reactivity :

Mouse

Background :

The 3G3 antibody reacts with mouse Foxp3, a 50-55 kDa transcription factor which is a central regulator of T cell activity and is critical for the development and function of regulatory T cells (Tregs). Foxp3 is expressed at constitutively high levels in Treg cells, which are further identified as being CD4+ CD25+. In resting conventional T cells (CD4+ CD25-) Foxp3 expression is restricted, and upon TCR activation is expressed only transiently and in a small proportion of cells. However, the growth factor TGF-beta has been shown to induce expression of Foxp3 in naïve T cells, driving their development into Foxp3+ Tregs, which are called “induced” or “adaptive” Tregs. These cells are phenotypically similar to so-called “natural” Tregs (CD4+ CD25high Foxp3+) which originate in the thymus and comprise the majority of Treg cells. Tregs are critical for maintaining peripheral tolerance and are implicated in the development of autoimmunity.It is important to review the literature in choosing an antibody for the Foxp3 antigen in flow cytometry, as the potential for high background or non-specific staining may be observed. The 3G3 antibody may be used for intracellular detection of Foxp3 in cells from mouse and Rhesus macaque.

ALT Names :

Forkhead box protein P3, Scurfin

Immunogen :

Immunogen information for this antibody is proprietary information.

Package Size :

100 μg

Uses :

Flow Cytometry

Storage :

It is recommended to store the product undiluted at 2-8°C and protected from prolonged exposure to light. Do not freeze.