CD86 (B7-2) Antibody (human), PE, clone IT2.2 | EMD Millipore MABF459 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

CD86 (B7-2) Antibody (human), PE, clone IT2.2

catalog :

MABF459

quantity :

100 tests

clonality :

monoclonal

host :

mouse

conjugate :

clone name :

IT2.2

The same clone is also sold as:

LifeSpan Biosciences: LS-C41120
Invitrogen: 62-0869-42, 53-0869-42, 64-0869-41, 63-0869-41, 16-0869-050, 53-0869-41, 51-0869-42, 12-0869-41, 25-0869-41, 14-0869-82, 16-0869-85, 63-0869-42, 25-0869-42, 13-0869-82, 12-0869-42, 51-0869-41, 17-0869-42, 46-0869-42, 17-0869-41, 16-0869-025, 64-0869-42, 46-0869-41, 56-0869-42, 15-0869-42
BioLegend: 305427, 305408, 305419, 305422, 305439, 305431, 305420, 305405, 305432, 305407, 305404, 305421, 305449, 305435, 305417, 305415, 305428, 305402, 305447, 305426, 305413, 305423, 305430, 305441, 305440, 305406, 305401, 305418, 305411, 305414, 305412, 305434, 305442, 305416, 305429, 305445, 305443, 305433, 305438, 305450, 305425
Rockland Immunochemicals: 200-308-N75, 200-326-N75
BD Biosciences: 555662, 555665, 555663, 555664

reactivity :

human

application :

immunohistochemistry, immunoprecipitation, flow cytometry

product information

Catalog Number :

MABF459

Subcategory :

Inflammation & Immunology

Product Name :

Anti-CD86 (B7-2) Antibody (human), PE, clone IT2.2

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P42081

Host Name :

Mouse

Antigen :

CD86

Clone :

IT2.2

Conjugate :

Purification Method :

Size Exclusion Chromatography

Isotype :

IgG2bκ

Product Description :

Anti-CD86 (B7-2) Antibody (human), PE, clone IT2.2

Cross Reactivity :

Human

Background :

The IT2.2 antibody reacts with human CD86, also known as B7-2, an 80 kDa cell surface protein which is a ligand for CD28, a co-stimulatory receptor for the T cell receptor (TCR). CD28 can also bind a second B7 ligand known as CD80 (B7-1). Both CD80 and CD86 are expressed on activated B cells and antigen-presenting cells. These ligands trigger CD28 signaling in concert with TCR activation to drive T cell proliferation, induce high-level expression of IL-2, impart resistance to apoptosis, and enhance T cell cytotoxicity. The interaction / co-stimulatory signaling between the B7 ligands and CD28 provides crucial communication between T cells and B cells or APCs to coordinate the adaptive immune response.The IT2.2 antibody may be used as a marker for CD86 expression on B cells, macrophages, and dendritic cells. It is reported to be cross-reactive with Rhesus, Cynomolgus and Common marmoset CD86.

ALT Names :

T-lymphocyte activation antigen CD86, Activation B7-2 antigen, B70, BU63, CTLA-4 counter-receptor B7.2, FUN-1, CD antigen CD86

Immunogen :

Immunogen information for this antibody is proprietary information.

Package Size :

100 tests

Uses :

Immunohistochemistry, Immunoprecipitation, Flow Cytometry

Storage :

It is recommended to store the product undiluted at 2-8°C and protected from prolonged exposure to light. Do not freeze.