This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
EMD Millipore
other brands :
Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava
product type :
antibody
product name :
CD4 Antibody (mouse), PE-Cy7, clone GK1.5
catalog :
MABF414
quantity :
100 μg
clonality :
monoclonal
host :
rat
conjugate :
PE/Cy7
clone name :
GK1.5

The same clone is also sold as:
reactivity :
mouse
application :
immunohistochemistry, immunoprecipitation, flow cytometry
product information
Catalog Number :
MABF414
Subcategory :
Inflammation & Immunology
Product Name :
Anti-CD4 Antibody (mouse), PE-Cy7, clone GK1.5
Product Type :
Antibodies
Clonality :
Monoclonal Antibody
Gene ID :
P06332
Host Name :
Rat
Antigen :
Cd4
Clone :
GK1.5
Conjugate :
PE-Cy7
Purification Method :
Size Exclusion Chromatography
Isotype :
IgG2bκ
Product Description :
Anti-CD4 Antibody (mouse), PE-Cy7, clone GK1.5
Cross Reactivity :
Mouse
Background :
The GK1.5 antibody reacts with mouse CD4, a 55 kDa protein which acts as a co-receptor for the T cell receptor (TCR) in its interaction with MHC Class II molecules on antigen-presenting cells. The extracellular domain of CD4 binds to the beta-2 domain of MHC Class II, while its cytoplasmic tail provides a binding site for the tyrosine kinase lck, facilitating the signaling cascade that initiates T cell activation. CD4 is typically expressed on thymocytes, certain mature T cell populations such as Th17 and T regulatory (Treg) cells, as well as on dendritic cells.The GK1.5 antibody is widely used as a phenotypic marker for CD4 expression. If used together, the GK1.5 antibody and an alternative antibody, Anti-Mouse CD4 clone RM4-5, will “compete” for binding, i.e. RM4-5 is able to block GK1.5 binding to cells. In contrast, the Anti-Mouse CD4 clone RM4-4 does not block binding of the GK1.5 antibody to cells (Arora S et al. 2006. Infect. Immun. 74: 4339-4348). The GK1.5 antibody is also reported to be cross-reactive with Syrian hamster CD4.
ALT Names :
T-cell surface glycoprotein CD4, T-cell differentiation antigen L3T4, T-cell surface antigen T4/Leu-3, CD4
Immunogen :
Immunogen information for this antibody is proprietary information.
Package Size :
100 μg
Uses :
Immunoprecipitation, Immunohistochemistry, Flow Cytometry
Storage :
It is recommended to store the product undiluted at 2-8°C and protected from prolonged exposure to light. Do not freeze.
company information
EMD Millipore
290 Concord Road
Billerica, Massachusetts 01821
bioscienceshelp@emdchemical.com
https://www.emdmillipore.com
888-854-3417
headquarters: United States
EMD Millipore is the Life Science division of Merck KGaA of Darmstadt, Germany

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