CD279 (PD-1) Antibody (mouse), PE, clone J43.1 | EMD Millipore MABF406 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

CD279 (PD-1) Antibody (mouse), PE, clone J43.1

catalog :

MABF406

quantity :

100 μg

clonality :

monoclonal

host :

hamsters

conjugate :

clone name :

J43.1

reactivity :

mouse

application :

immunohistochemistry, immunoprecipitation, flow cytometry

product information

Catalog Number :

MABF406

Subcategory :

Inflammation & Immunology

Product Name :

Anti-CD279 (PD-1) Antibody (mouse), PE, clone J43.1

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

Q02242

Host Name :

Armenian Hamster

Antigen :

Pdcd1

Clone :

J43.1

Conjugate :

Purification Method :

Size Exclusion Chromatography

Isotype :

IgG

Product Description :

Anti-CD279 (PD-1) Antibody (mouse), PE, clone J43.1

Cross Reactivity :

Mouse

Background :

The J43.1 antibody is specific for mouse CD279, also known as programmed death-1 (PD-1), a 55 kDa glycoprotein which can co-regulate T cell antigen receptor signaling and therefore modulate T cell activation. PD-1 exists in a monomeric form that is expressed by CD4- CD8- thymocytes, where it participates in the processes of clonal selection, elimination of autoreactive lymphocytes, and development of tolerance. PD-1 expression is also inducible upon activation of mature T cells, where it has been proposed to interact with the co-stimulatory receptor CD80 to limit T cell activation. Two ligands for PD-1, known as PD-L1 (B7-H1) and PD-L2 (B7-DC) are differentially expressed on T and B cells, monocytes, macrophages, NK cells or dendritic cells. PD-1 is a member of a family of receptors including CD28 and CTLA-4 (CD152), which interact with “B7” ligands to provide a balance of co-stimulatory /co-inhibitory signaling important in T cell activation, tolerance, and autoimmunity.The J43.1 antibody may be used as a marker for PD-1 expression, and is commonly used for analysis of receptor-ligand interaction and function(s) in vitro and in vivo.

ALT Names :

Programmed cell death protein 1, Protein PD-1, mPD-1, CD279

Immunogen :

Immunogen information for this antibody is proprietary information.

Package Size :

100 μg

Uses :

Immunoprecipitation, Immunohistochemistry, Flow Cytometry

Storage :

It is recommended to store the product undiluted at 2-8°C and protected from prolonged exposure to light. Do not freeze.