DC-STAMP Antibody, clone 1A2 | EMD Millipore MABF39 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

DC-STAMP Antibody, clone 1A2

catalog :

MABF39

quantity :

100 μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

1A2

reactivity :

human, mouse

application :

western blot, immunocytochemistry, flow cytometry

citations: 7

Published Application/Species/Sample/Dilution	Reference
immunocytochemistry; human; 1:50; loading ...; fig 3a	Verma S, Leikina E, Melikov K, Gebert C, Kram V, Young M, et al. Cell-surface phosphatidylserine regulates osteoclast precursor fusion. J Biol Chem. 2018;293:254-270 pubmed publisher
western blot; mouse; fig 2	Gurt I, Artsi H, Cohen Kfir E, Hamdani G, Ben Shalom G, Feinstein B, et al. The Sirt1 Activators SRT2183 and SRT3025 Inhibit RANKL-Induced Osteoclastogenesis in Bone Marrow-Derived Macrophages and Down-Regulate Sirt3 in Sirt1 Null Cells. PLoS ONE. 2015;10:e0134391 pubmed publisher
immunocytochemistry; mouse; 1:100	Wang Y, Brooks P, Jang J, Silver A, Arora P, McCulloch C, et al. Role of actin filaments in fusopod formation and osteoclastogenesis. Biochim Biophys Acta. 2015;1853:1715-24 pubmed publisher
	Kim H, Takegahara N, Walsh M, Middleton S, Yu J, Shirakawa J, et al. IgSF11 regulates osteoclast differentiation through association with the scaffold protein PSD-95. Bone Res. 2020;8:5 pubmed publisher
	Lee K, Park K, Hwang J, Lee M, Yoon D, Ryu H, et al. Inhibition of STAT5A promotes osteogenesis by DLX5 regulation. Cell Death Dis. 2018;9:1136 pubmed publisher
	Fu J, Li S, Feng R, Ma H, Sabeh F, Roodman G, et al. Multiple myeloma-derived MMP-13 mediates osteoclast fusogenesis and osteolytic disease. J Clin Invest. 2016;126:1759-72 pubmed publisher
	Islam R, Bae H, Yoon W, Woo K, Baek J, Kim H, et al. Pin1 regulates osteoclast fusion through suppression of the master regulator of cell fusion DC-STAMP. J Cell Physiol. 2014;229:2166-74 pubmed publisher

product information

Catalog Number :

MABF39

Subcategory :

Inflammation & Immunology

Product Name :

Anti-DC-STAMP Antibody, clone 1A2

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

Q9H295

Host Name :

Mouse

Antigen :

DC-STAMP

Clone :

1A2

Conjugate :

Purified

Isotype :

IgG2aκ

Product Description :

Anti-DC-STAMP Antibody, clone 1A2

Cross Reactivity :

Mouse;Human

Background :

Dendritic cell-specific transmembrane protein (DC-STAMP) is a recently described, 470-amino acid, transmembrane protein with a critical role in TNSF11-mediated osteogenesis and giant cell formation. It has also been implicated in a role for inducing tartrate-resistant acid phosphatase expression in osteoclast precursors. DC-STAMP was originally discovered in myeloid dendritic cells as an interleukin-4 (IL-4)-inducible protein consisting of seven transmembrane domains. DC-STAMP is widely expressed with highest levels observed in kidney, liver, lung and lymph node, along with preferential expression in both mature and immature dendritic cells. Lower levels of expression have been observed in bone marrow, leukocytes, pancreas and spleen, and also in freshly isolated B-cells and peripheral blood mononuclear cells (PBMC).

ALT Names :

transmembrane 7 superfamily member 4;DC-specific transmembrane protein;IL-Four INDuced;IL-Four (IL-4) induced;Dendritic cell-specific transmembrane protein;Dendritic cells (DC)-specific transmembrane protein;IL-4-induced protein

Immunogen :

KLH-conjugated linear peptide corresponding to human DC-STAMP at the fourth extracellular domain.

Specificity :

This antibody recognizes DC-STAMP at the fourth extracellular domain.

Package Size :

100 μg

Uses :

Western Blotting;Flow Cytometry;Immunocytochemistry

Storage :

Stable for 1 year at 2-8°C from date of receipt