This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
EMD Millipore
other brands :
Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava
product type :
antibody
product name :
CD11c Antibody (mouse), FITC, clone N418
catalog :
MABF374
quantity :
100 μg
clonality :
monoclonal
host :
hamsters
conjugate :
FITC
clone name :
N418

The same clone is also sold as:
reactivity :
mouse
application :
immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry
product information
Catalog Number :
MABF374
Subcategory :
Inflammation & Immunology
Product Name :
Anti-CD11c Antibody (mouse), FITC, clone N418
Product Type :
Antibodies
Clonality :
Monoclonal Antibody
Gene ID :
Q9QXH4
Host Name :
Armenian Hamster
Antigen :
Itgax
Clone :
N418
Conjugate :
FITC
Purification Method :
Size Exclusion Chromatography
Isotype :
IgG
Product Description :
Anti-CD11c Antibody (mouse), FITC, clone N418
Cross Reactivity :
Mouse
Background :
The N418 antibody reacts with mouse CD11c, also known as integrin alpha X. This 150 kDa cell surface glycoprotein is part of a family of integrin receptors that mediate adhesion between cells (cell-cell) and components of the extracellular matrix, e.g. fibrinogen (cell-matrix). In addition, integrins are active signaling receptors which recruit leukocytes to inflammatory sites and promote cell activation. Complete, functional integrin receptors consist of distinct combinations of integrin chains which are differentially expressed. Integrin alpha X (CD11c) assembles with Integrin beta-2 (CD18) into a receptor complex known as CR4 which can bind and induce signaling throµgh ICAMs and VCAM-1 on endothelial cells and can also facilitate removal of iC3b bearing foreign cells.The N418 antibody is widely used as a marker for CD11c expression on dendritic cells (DC), often in parallel with markers for CD11b, for identification of developmental stages and mature subsets of this cell type. CD11c is prominently expressed on tissue macrophages, and is also detected on some types of activated T cells and intestinal intraepithelial lymphocytes (IEL).
ALT Names :
Integrin alpha-Xl, CD11 antigen-like family member C, Leukocyte adhesion glycoprotein p150,95 alpha chain, Leukocyte adhesion receptor p150,95, CD11c
Immunogen :
Immunogen information for this antibody is proprietary information.
Package Size :
100 μg
Uses :
Immunoprecipitation, Immunohistochemistry, Immunofluorescence, Flow Cytometry
Storage :
It is recommended to store the product undiluted at 2-8°C and protected from prolonged exposure to light. Do not freeze.
company information
EMD Millipore
290 Concord Road
Billerica, Massachusetts 01821
bioscienceshelp@emdchemical.com
https://www.emdmillipore.com
888-854-3417
headquarters: United States
EMD Millipore is the Life Science division of Merck KGaA of Darmstadt, Germany

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