CD45RO (human) Antibody, PE/Cy5, clone UCHL1 | EMD Millipore MABF358 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

CD45RO (human) Antibody, PE/Cy5, clone UCHL1

catalog :

MABF358

quantity :

100 tests

clonality :

monoclonal

host :

mouse

conjugate :

PE-Cy5

clone name :

UCHL1

The same clone is also sold as:

MyBioSource: MBS213022
BioLegend: 304205, 304259, 304225, 304244, 304227, 304238, 304220, 304242, 304239, 304247, 304233, 304261, 304263, 304216, 304235, 304248, 304250, 304245, 304234, 304232, 304229, 304254, 304208, 304231, 304264, 304224, 304221, 304252, 304236, 304228, 304210, 304255, 304237, 983102, 304249, 304204, 304218, 304202, 304230, 304215, 304246, 304223, 304222, 304262, 304251, 304206, 304226, 304257, 304212, 304217
Abnova: MAB4436, MAB16251, MAB11300, MAB4434, MAB12231
Abcam: ab210385, ab23, ab86080
Rockland Immunochemicals: 200-302-N71, 200-308-N71, 200-326-N71
Miltenyi Biotec: 130-113-548, 130-113-554, 130-113-546, 130-114-081, 130-114-075, 130-114-077, 130-108-064, 130-113-550, 130-114-072, 130-114-073, 130-114-080, 130-114-079, 130-113-547, 130-114-074, 130-113-552, 130-113-551, 130-113-553, 130-114-078, 130-113-549, 130-114-076, 130-113-555
Dako: M0742
Invitrogen: 48-0457-42, 67-0457-42, 15-0457-42, 14-0457-37, 25-0457-42, MA1-33243, 17-0457-42, 46-0457-42, MHCD45RO05, 12-0457-42, 17-0457-41, 63-0457-42, MA1-10235, 61-0457-41, 14-0457-95, MA5-11532, MHCD45RO04, 25-0457-41, 11-0457-42, 62-0457-42, 63-0457-41, 78-0457-42, MA1-10236, 64-0457-42, MA1-19452, MHCD45RO31, MHCD45RO01, 14-0457-80, 47-0457-41, 13-0457-82, MA1-19782, 47-0457-42, 46-0457-41, 14-0457-82, 64-0457-41, 61-0457-42
BD Biosciences: 649460, 655160, 555493, 555492, 561887, 555491, 560607, 347967, 555494, 563750, 649452, 561889, 559865, 562327, 337168, 340438, 560899, 563749, 561137, 649459, 562299, 560608, 561888, 561136
US Biological: 138519
Exbio: T7-498-T100, 1F-498-T025, T5-498-T100, 1P-498-T025, 11-498-C100, 1A-498-T100, 1P-498-T100, 1A-498-T025, 1F-498-T100, T7-498-T025, T5-498-T025, 11-498-C025
LifeSpan Biosciences: LS-C41089, LS-C134445, LS-C134447, LS-C106016, LS-C134448, LS-C134444, LS-C45114, LS-C340234, LS-C87550, LS-C87558, LS-C134446
Novus Biologicals: NBP2-29631, NBP2-33104
Absolute Antibody: Ab00604-2.3, Ab00604-23.0, Ab00604-2.0
Bio-Rad: MCA461GT, MCA461GA, MCA461F, MCA461C, MCA461PE, MCA461SBV515
Santa Cruz Biotechnology: sc-1183
Leica Biosystems: PA0151
ImmuQuest: IQ640HRP
Beckman Coulter: IM2712U
OriGene: CF807197, TA353405L, TA327643, SM1117PT, TA320454, TA807197, SM1117PS, SM1117S, SM1117F, TA807197S

reactivity :

human

application :

western blot, immunohistochemistry, immunoprecipitation, flow cytometry

citations: 6

Reference
Powis R, Mutsaers C, Wishart T, Hunter G, Wirth B, Gillingwater T. Increased levels of UCHL1 are a compensatory response to disrupted ubiquitin homeostasis in spinal muscular atrophy and do not represent a viable therapeutic target. Neuropathol Appl Neurobiol. 2014;40:873-87 pubmed publisher
Newman A, Selkoe D, Dettmer U. A new method for quantitative immunoblotting of endogenous ?-synuclein. PLoS ONE. 2013;8:e81314 pubmed publisher
Kuang Z, Yao Y, Shi Y, Gu Z, Sun Z, Tso J. Winter hibernation and UCHL1-p34cdc2 association in toad oocyte maturation competence. PLoS ONE. 2013;8:e78785 pubmed publisher
Ummanni R, Jost E, Braig M, Lohmann F, Mundt F, Barett C, et al. Ubiquitin carboxyl-terminal hydrolase 1 (UCHL1) is a potential tumour suppressor in prostate cancer and is frequently silenced by promoter methylation. Mol Cancer. 2011;10:129 pubmed publisher
Siman R, Toraskar N, Dang A, McNeil E, McGarvey M, Plaum J, et al. A panel of neuron-enriched proteins as markers for traumatic brain injury in humans. J Neurotrauma. 2009;26:1867-77 pubmed publisher
Okochi Takada E, Nakazawa K, Wakabayashi M, Mori A, Ichimura S, Yasugi T, et al. Silencing of the UCHL1 gene in human colorectal and ovarian cancers. Int J Cancer. 2006;119:1338-44 pubmed

product information

Catalog Number :

MABF358

Subcategory :

Inflammation & Immunology

Product Name :

Anti-CD45RO (human) Antibody, PE/Cy5, clone UCHL1

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P08575

Host Name :

Mouse

Antigen :

CD45RO (human)

Clone :

UCHL1

Conjugate :

PE-Cy5

Isotype :

IgG2aκ

Product Description :

Anti-CD45RO (human) Antibody, PE/Cy5, clone UCHL1

Cross Reactivity :

Human

Background :

Receptor-type tyrosine-protein phosphatase C, also known as Leukocyte common antigen (L-CA) or CD45 and encoded by the human gene PTPRC or CD45 is a transmembrane glycoprotein that belongs to the PTP family. PTPs are signaling molecules that regulate cellular process like cell growth, differentiation and mitotic cycle. CD45 has many isoforms that are distributed throughout the immune system according to cell type. These arise because of alternative splicing of RA, RB, and RC exons. CD45 and its isoforms non-covalently associate with lymphocyte phosphatase-associated phosphoprotein (LPAP) on T and B lymphocytes. CD45RO is one of the isoforms of CD45 that facilitates T cell activation. It is also the shortest isform which lack the RA, RB, and RC exons. Mutations in CD45 have been associated with mulitple sclerosis and severe combined immunodeficiency.

ALT Names :

Receptor-type tyrosine-protein phosphatase C;Leukocyte common antigen;L-CA;T200;CD45;CD45RO

Immunogen :

Cultured T cells from an IL-2 dependent T-cell line (CA1) prepared from human peripheral blood.

Specificity :

This antibody is commonly used in combination with antibodies against CD45RA to discern memory and naïve T cells.

Package Size :

100 tests

Uses :

Flow Cytometry;Western Blotting;Immunohistochemistry;Immunoprecipitation

Storage :

The antibody solution should be stored undiluted at 2-8°C and protected from prolonged exposure to light. Do not freeze.