TNF-α (human) Antibody, PE, clone MAb11 | EMD Millipore MABF352 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

TNF-α (human) Antibody, PE, clone MAb11

catalog :

MABF352

quantity :

100 tests

clonality :

monoclonal

host :

mouse

conjugate :

clone name :

MAb11

The same clone is also sold as:

Exbio: 1P-688-T025, 11-688-C025, 1A-688-T100, 1F-688-T025, 1P-688-T100, 1A-688-T025, 1F-688-T100, 11-688-C100
BD Biosciences: 557068, 562083, 557996, 561311, 560678, 562784, 554513, 561023, 559321, 557647, 559071, 554512, 558882, 562082, 560923, 554511, 554514, 554510, 560679, 552889
BioLegend: 502939, 502941, 502950, 502943, 502932, 502947, 502940, 502925, 502949, 502935, 502909, 502923, 502904, 502913, 502944, 502916, 502926, 502915, 502936, 502908, 502902, 502927, 502931, 502920, 502906, 502901, 502928, 502938, 502946, 502903, 502912, 502924, 502917, 502929, 502948, 502937, 502945, 502930
LifeSpan Biosciences: LS-C204485, LS-C204334, LS-C106694, LS-C107007, LS-C41025
Invitrogen: 11-7349-82, 25-7349-41, 56-7349-42, 48-7349-41, 14-7349-85, 12-7349-41, 606-7349-41, 11-7349-81, 45-7349-42, 13-7349-85, 12-7349-82, 14-7349-81, 13-7349-81, 606-7349-42, 53-7349-42, 11-7349-41, 61-7349-42, 17-7349-41, 56-7349-41, 48-7349-42, 25-7349-82, 17-7349-82
OriGene: AM26711AC-N, TA700026, AM26711RP-N, AM26711PU-N, AM26711FC-N, TA320489

reactivity :

human

application :

immunohistochemistry, neutralization, flow cytometry

citations: 2

Reference
Ng D, Humphries J, Byron A, Millon FrÃ©millon A, Humphries M. Microtubule-dependent modulation of adhesion complex composition. PLoS ONE. 2014;9:e115213 pubmed publisher
Schwenk J, Poetz O, Zeillinger R, Joos T. A Miniaturized Ligand Binding Assay for EGFR. Int J Proteomics. 2012;2012:247059 pubmed publisher

product information

Catalog Number :

MABF352

Subcategory :

Inflammation & Immunology

Product Name :

Anti-TNF-α (human) Antibody, PE, clone MAb11

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P01375

Host Name :

Mouse

Antigen :

TNF-α (human)

Clone :

MAb11

Conjugate :

Isotype :

IgG1κ

Product Description :

Anti-TNF-α (human) Antibody, PE, clone MAb11

Cross Reactivity :

Human

Background :

Tumor Necrosis Factor α (TNF-alpha, cachectin) is a cytokine, produced by variety of cell types, that is involved in mediation of the inflammatory response, resistance to infection, and resistance to tumor growth. TNF-alpha is known to bind to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. TNF-α is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia. Studies have shown that under certain conditions it can stimulate cell proliferation and induce cell differentiation. The TNF intracellular domain (ICD) form induces IL12 production in dendritic cells. Mutations in TNF-alpha have been associated with Psoriatic Arthritis (PSORAS): an inflammatory, seronegative arthritis associated with psoriasis. Human and mouse TNF-α are approximately 79% homologous at the amino acid level and exhibit cross-species reactivity. TNF-alpha induced protein 6 may be involved in cell-cell and cell-matrix interactions during normal inflammatory responses and during tumorigenesis.

ALT Names :

Tumor necrosis factor;Cachectin;TNF-alpha;Tumor necrosis factor ligand superfamily member 2;TNF-a

Immunogen :

E. coli-expressed, recombinant human TNF-α

Package Size :

100 tests

Uses :

Flow Cytometry;Immunohistochemistry;Neutralizing

Storage :

The antibody solution should be stored undiluted at 2-8°C and protected from prolonged exposure to light. Do not freeze.