CD282 (TLR2) (human) Antibody, PE, clone TL2.1 | EMD Millipore MABF349 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

CD282 (TLR2) (human) Antibody, PE, clone TL2.1

catalog :

MABF349

quantity :

100 tests

clonality :

monoclonal

host :

mouse

conjugate :

clone name :

TL2.1

The same clone is also sold as:

Abnova: MAB0067
OriGene: TA336462, SM1825BS, TA320480
Santa Cruz Biotechnology: sc-21759 AC, sc-21759
Abcam: ab13553, ab171568, ab9100
BioLegend: 309720, 309719, 309705, 309721, 309706, 309712, 309714, 309708, 309702, 309722, 309717, 309718, 309707
LifeSpan Biosciences: LS-C148157, LS-C492, LS-C122225, LS-C122226, LS-C202275, LS-C139996, LS-C139995, LS-C148160, LS-C148159, LS-C139997, LS-C40823, LS-C148158, LS-C18672
Novus Biologicals: NB100-56726, NB100-56722
Enzo Life Sciences: ALX-804-323F-T100, ALX-804-323PF-C100, ALX-804-323PF-C050, ALX-804-323-C050
Invitrogen: MA5-16204, 14-9922-80, 11-9922-42, 16-9922-82, 16-9922-050, 13-9922-80, 11-9922-41, 16-9922-38, 13-9922-82, 17-9922-42, 17-9922-41, 12-9922-42, 16-9922-025, 12-9922-41, 53-9922-42, MA5-16200, 14-9922-82

reactivity :

human

application :

flow cytometry

product information

Catalog Number :

MABF349

Subcategory :

Inflammation & Immunology

Product Name :

Anti-CD282 (TLR2) (human) Antibody, PE, clone TL2.1

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

O60603

Host Name :

Mouse

Antigen :

CD282 (TLR2) (human)

Clone :

TL2.1

Conjugate :

Isotype :

IgG2aκ

Product Description :

Anti-CD282 (TLR2) (human) Antibody, PE, clone TL2.1

Cross Reactivity :

Human

Background :

CD282, also known as TLR2 or TIL4, is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. CD282 has been shown to interact with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Additionally, CD282 has been shown to interact with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. CD282 is implied to be activated by MYD88 and TRAF6, which leads to NF-kappa-B activation, cytokine secretion and the inflammatory response. CD282 may also promote apoptosis in response to lipoproteins. CD282 has been shown to interact with LY96, TLR1 and TLR6 (via extracellular domain), TICAM1, MYD88 , CNPY3 and ATG16L1. CD282 is highly expressed in peripheral blood leukocytes, in particular in monocytes, in bone marrow, lymph node and in spleen. It is also detected in lung and in fetal liver. Genetic variations in CD282 are associated with susceptibility to leprosy: a chronic disease associated with depressed cellular (but not humoral) immunity. Recent studies have shown that the impaired function of the Trp-677 polymorphism provides a molecular mechanism for the poor cellular immune response associated with lepromatous leprosy.

ALT Names :

Toll-like receptor 2;Toll/interleukin-1 receptor-like protein 4;CD282;TLR2

Immunogen :

Human TLR2- transfected CHO cells

Package Size :

100 tests

Uses :

Flow Cytometry

Storage :

The antibody solution should be stored undiluted at 2-8°C and protected from prolonged exposure to light. Do not freeze.