TGF-β1 (human) Antibody, PE, clone TW4-2F8 | EMD Millipore MABF348 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

TGF-β1 (human) Antibody, PE, clone TW4-2F8

catalog :

MABF348

quantity :

100 tests

clonality :

monoclonal

host :

mouse

conjugate :

clone name :

TW4-2F8

reactivity :

human

application :

flow cytometry

product information

Catalog Number :

MABF348

Subcategory :

Inflammation & Immunology

Product Name :

Anti-TGF-β1 (human) Antibody, PE, clone TW4-2F8

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P01137

Host Name :

Mouse

Antigen :

TGF-β1 (human)

Clone :

TW4-2F8

Conjugate :

Isotype :

IgG1κ

Product Description :

Anti-TGF-β1 (human) Antibody, PE, clone TW4-2F8

Cross Reactivity :

Human

Background :

LAP, also known as TGF-beta1 or TGF-β1, belongs to the TGF-beta family. TGF-β1 is a multifunctional protein that controls proliferation, differentiation and other functions in various cell types. TGF-β1 is synthesized by many cells that have specific receptors for it. It positively and negatively regulates many other growth factors. TGF-β1 plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts. The 'straitjacket' and 'arm' domains encircle the growth factor monomers and are fastened together by strong bonding between Lys-56 and Tyr-103/Tyr-104. Activation of TGF-β1 requires the binding of integrin alpha-V to an RGD sequence in the prodomain and exertion of force on this domain, which is held in the extracellular matrix by latent TGF-beta binding proteins. The physical force unfastens the straitjacket and releases the active growth factor dimer.

ALT Names :

Transforming growth factor beta-1;TGF-beta-1;Latency-associated peptide;LAP;TGFB1;TGFB;TGF-β1

Immunogen :

LAP (TGF-β)

Package Size :

100 tests

Uses :

Flow Cytometry

Storage :

The antibody solution should be stored undiluted at 2-8°C and protected from prolonged exposure to light. Do not freeze.