IL-10 (human) Antibody, PE, clone JES3-19F1 | EMD Millipore MABF328 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

IL-10 (human) Antibody, PE, clone JES3-19F1

catalog :

MABF328

quantity :

100 tests

clonality :

monoclonal

host :

rat

conjugate :

clone name :

JES3-19F1

The same clone is also sold as:

BioLegend: 506804, 506812, 506806, 506807, 506814, 506811, 506802, 506813, 506801
BD Biosciences: 554703, 554707, 562400, 562035, 554706, 554705, 554704, 559330, 562036
Santa Cruz Biotechnology: sc-53705

reactivity :

human

application :

flow cytometry

product information

Catalog Number :

MABF328

Subcategory :

Inflammation & Immunology

Product Name :

Anti-IL-10 (human) Antibody, PE, clone JES3-19F1

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P22301

Host Name :

Rat

Antigen :

IL-10 (human)

Clone :

JES3-19F1

Conjugate :

Isotype :

IgG2aκ

Product Description :

Anti-IL-10 (human) Antibody, PE, clone JES3-19F1

Cross Reactivity :

Human

Background :

Interleukin-10 (IL-10), originally known as Cytokine Synthesis Inhibitory Factor (CSIF) is a protein that shares over 80% sequence homology with the Epstein-Barr Virus protein BCRFI. IL-10 down regulates the expression of Th1 cytokines, major histocompatibility complex class II antigens, and costimulatory molecules on macrophages. It also enhaces B cell survival, proliferation, and antibody production. IL-10 inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T-cells. IL-10 is produced by a variety of cell lines, including T-cells, macrophages, mast cells and other cell types. A polymorphism in IL10 promoter region is associated with resistance to graft-versus-host disease (GVHDS), a major complication of allogeneic bone marrow transplantation, in which mature donor T-cells that contaminate the allogeneic bone marrow recognize the tissues of the recipient as foreign, causing a severe inflammatory disease. Knockout studies suggest that IL-10 is an immunoregulator in the intestinal tract.

ALT Names :

Interleukin-10;IL-10;Cytokine synthesis inhibitory factor;CSIF

Immunogen :

COS-expressed recombinant human IL-10

Package Size :

100 tests

Uses :

Flow Cytometry

Storage :

The antibody solution should be stored undiluted at 2-8°C and protected from prolonged exposure to light. Do not freeze.