CD45 (mouse) Antibody, APC, clone 30-F11 | EMD Millipore MABF319 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

CD45 (mouse) Antibody, APC, clone 30-F11

catalog :

MABF319

quantity :

100 μg

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

30-F11

The same clone is also sold as:

Rockland Immunochemicals: 200-502-N83, 200-526-N83, 200-508-N83
LifeSpan Biosciences: LS-C106288, LS-C141314, LS-C141315, LS-C141313
Tonbo Biosciences: 20-0451
Novus Biologicals: NB100-77417, NBP2-80652
Santa Cruz Biotechnology: sc-53665
R&D Systems: BAM114, FAB114S-100UG, FAB114U-100UG, FAB114G-100UG, MAB114-100, FAB114N-100UG, FAB114R-025UG, FAB114T-100UG, FAB114A, FAB114V-025, FAB114F
Invitrogen: 69-0451-82, 64-0451-82, 58-0451-80, 58-0451-82, 14-0451-85, 67-0451-80, 61-0451-82, 53-0451-80, 606-0451-82, 12-0451-82, 35-0451-80, MCD4501, 16-0451-38, 505-0451-80, 15-0451-81, 25-0451-81, 17-0451-82, 13-0451-85, 12-0451-83, 45-0451-82, 56-0451-80, 15-0451-83, 62-0451-80, MCD4505, 48-0451-80, 11-0451-85, 69-0451-80, 63-0451-80, 47-0451-80, 48-0451-82, 35-0451-82, 13-0451-82, 45-0451-80, 63-0451-82, 15-0451-82, 13-0451-81, 47-0451-82, 16-0451-025, 11-0451-82, 606-0451-80, 14-0451-81, 12-0451-81, 67-0451-82, 56-0451-82, 62-0451-82, 78-0451-82, 17-0451-83, 25-0451-82, 16-0451-85, MCD4528, MCD4530, 16-0451-050, 14-0451-82, 11-0451-81, MCD4517, 505-0451-82, 64-0451-80, 53-0451-82
BD Biosciences: 563891, 557235, 561087, 550539, 557659, 562420, 561868, 561487, 563053, 553081, 553078, 560501, 553079, 563890, 562166, 564279, 560510, 561869, 561088, 561047, 559864, 553077, 561018, 550994, 563410, 561870, 564590, 561037, 553080, 552848, 553082, 553076
BioLegend: 103177, 103146, 103154, 103130, 103139, 103178, 103137, 103169, 103106, 103166, 103127, 103115, 103157, 103114, 103126, 103164, 103132, 103163, 103147, 103123, 103134, 103111, 103102, 103161, 103165, 103171, 103135, 103129, 103121, 103174, 103103, 103109, 103124, 103133, 103101, 103167, 103112, 103173, 103125, 103131, 103113, 103140, 103107, 103159, 103141, 103110, 103104, 103122, 103136, 103145, 103172, 103155, 103144, 103175, 103168, 103149, 103151, 103116, 103128, 103138, 103105, 103176, 103179, 103108, 103153
OriGene: TA320448
Miltenyi Biotec: 130-123-900, 130-123-784, 130-123-904, 130-116-500, 130-117-498, 130-118-687, 130-118-559, 130-118-953, 130-117-348, 130-116-535, 130-117-529, 130-123-879, 130-119-130, 130-124-209
Abnova: MAB15485, MAB10967, MAB15484, MAB15482, MAB15486, MAB15483, MAB15480, MAB15481

reactivity :

mouse

application :

western blot, immunohistochemistry, immunoprecipitation, flow cytometry

citations: 6

Reference
Aqbi H, Tyutyunyk Massey L, Keim R, Butler S, Thekkudan T, Joshi S, et al. Autophagy-deficient breast cancer shows early tumor recurrence and escape from dormancy. Oncotarget. 2018;9:22113-22122 pubmed publisher
Bakst R, Xiong H, Chen C, Deborde S, Lyubchik A, Zhou Y, et al. Inflammatory Monocytes Promote Perineural Invasion via CCL2-Mediated Recruitment and Cathepsin B Expression. Cancer Res. 2017;77:6400-6414 pubmed publisher
McFarland B, Marks M, Rowse A, Fehling S, Gerigk M, Qin H, et al. Loss of SOCS3 in myeloid cells prolongs survival in a syngeneic model of glioma. Oncotarget. 2016;7:20621-35 pubmed publisher
Woods L, Camden J, El Sayed F, Khalafalla M, Petris M, Erb L, et al. Increased Expression of TGF-Î² Signaling Components in a Mouse Model of Fibrosis Induced by Submandibular Gland Duct Ligation. PLoS ONE. 2015;10:e0123641 pubmed publisher
Sharif O, Matt U, Saluzzo S, Lakovits K, Haslinger I, Furtner T, et al. The scavenger receptor CD36 downmodulates the early inflammatory response while enhancing bacterial phagocytosis during pneumococcal pneumonia. J Immunol. 2013;190:5640-8 pubmed publisher
Sangaletti S, Stoppacciaro A, Guiducci C, Torrisi M, Colombo M. Leukocyte, rather than tumor-produced SPARC, determines stroma and collagen type IV deposition in mammary carcinoma. J Exp Med. 2003;198:1475-85 pubmed

product information

Catalog Number :

MABF319

Subcategory :

Inflammation & Immunology

Product Name :

Anti-CD45 (mouse) Antibody, APC, clone 30-F11

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P06800

Host Name :

Rat

Antigen :

CD45 (mouse)

Clone :

30-F11

Conjugate :

Purified

Isotype :

IgG2bκ

Product Description :

Anti-CD45 (mouse) Antibody, APC, clone 30-F11

Cross Reactivity :

Mouse

Background :

CD45, also known as PTPRC, is a receptor-tyrosine phosphatase required for antigen-induced signaling in T-cells and B-cells. CD 45 belongs to the protein-tyrosine phosphatase family, receptor class 1/6 subfamily.It also contains 2 fibronectin type-III domains and 2 tyrosine-protein phosphatase domains. CD45 has been shown to play an important role in T-cell activation through the antigen receptor. CD45 also is suggested to act as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one is suggested to affect the substrate specificity of the first domain. Upon T-cell activation, CD45 recruits and dephosphorylates SKAP1 and FYN. Furthermore, it has been shown to dephosphorylate LYN, and modulate LYN activity. Interestingly, CD45 has been associated with several Src-family tyrosine kinases, which are inhibited by tyrosine phosphorylation in their c-termini, suggesting a mechanism for signaling by CD45. CD45 has been shown to bind with GANAB and PRKCSH. Additionally, it interacts with SKAP1 and DPP4, whereas the interaction is enhanced in a interleukin-12-dependent manner in activated lymphocytes. Mutations in CD45 have been associated with Multiple Sclerosis (MS) and severe combined immunodeficiency (SCID), a genetically and clinically heterogeneous group of rare congenital disorders characterized by impairment of both humoral and cell-mediated immunity, leukopenia, and low or absent antibody levels.

ALT Names :

Receptor-type tyrosine-protein phosphatase C;Leukocyte common antigen;L-CA;T200;CD45

Immunogen :

Mouse thymus or spleen

Package Size :

100 μg

Uses :

Flow Cytometry;Immunohistochemistry;Western Blotting;Immunoprecipitation

Storage :

The antibody solution should be stored undiluted at 2-8°C and protected from prolonged exposure to light. Do not freeze.