CD3 (mouse) Antibody, PE, clone 17A2 | EMD Millipore MABF313 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

CD3 (mouse) Antibody, PE, clone 17A2

catalog :

MABF313

quantity :

200 μg

clonality :

monoclonal

host :

rat

conjugate :

clone name :

17A2

The same clone is also sold as:

Miltenyi Biotec: 130-117-510, 130-118-958, 130-119-801, 130-125-225, 130-119-135, 130-097-621, 130-118-849, 130-123-282, 130-102-314, 130-117-785
Invitrogen: 69-0032-82, 47-0032-82, 14-0032-85, 50-0032-82, 14-0032-81, 53-0032-80, 56-0032-82, 58-0032-82, 15-0032-82, 61-0032-80, 17-0032-82, 17-0032-80, 46-0032-82, 67-0032-82, 16-0032-82, 61-0032-82, 16-0032-025, 12-0032-82, 16-0032-38, 11-0032-80, 63-0032-80, 15-0032-80, 48-0032-82, 58-0032-80, 16-0032-85, 14-0032-86, 69-0032-80, 47-0032-80, 67-0032-80, 14-0032-82, 56-0032-80, 25-0032-80, 50-0032-80, 12-0032-80, 63-0032-82, 16-0032-81, 48-0032-80, 13-0032-82, 11-0032-82, 78-0032-82, 25-0032-82, 53-0032-82, 16-0032-86, 16-0032-050, 46-0032-80
Bio X Cell: BE0002-100MG, BE0002-25MG, BE0002-1MG, BE0002-5MG, BE0002-50MG

reactivity :

mouse

application :

immunohistochemistry, immunoprecipitation, flow cytometry

citations: 1

Reference
Gautron L, Rutkowski J, Burton M, Wei W, Wan Y, Elmquist J. Neuronal and nonneuronal cholinergic structures in the mouse gastrointestinal tract and spleen. J Comp Neurol. 2013;521:3741-67 pubmed publisher

product information

Catalog Number :

MABF313

Subcategory :

Inflammation & Immunology

Product Name :

Anti-CD3 (mouse) Antibody, PE, clone 17A2

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P22646

Host Name :

Rat

Antigen :

CD3 (mouse)

Clone :

17A2

Conjugate :

Isotype :

IgG2bκ

Product Description :

Anti-CD3 (mouse) Antibody, PE, clone 17A2

Cross Reactivity :

Mouse

Background :

CD3, also known as T3, is a member of the Ig and the ITAM superfamilies. The CD3 complex is composed of six polypeptides with usually four different transmembrane CD3 chains, gamma, delta, epsilon and zeta. CD3 is primarily expressed on T cells, NK-T cells, and at different levels on thymocytes during T cell differentiation. CD3 plays a critical role in TCR signal transduction, T cell activation, and antigen recognition by binding the peptide/MHC antigen complex. The CD3 antigen is present in early thymocytes, and has been considered the best all-around T cell marker. The positive staining of this marker may represent a sign of early commitment to the T cell lineage. In cortical thymocytes, during early stages of maturation, the CD3 antigen is predominantly present in the cell cytoplasm. In medullary thymocyles, the CD3 antigen is predominantly detected on the cell surface. The majority of T cell neoplasms also expresses CD3, but it is absent from non-T-cell lymphoid malignancies. CD3 complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. Defects in this gene cause immunodeficiency. This gene has also been linked to a susceptibility to type I diabetes in women.

ALT Names :

T-cell surface glycoprotein CD3 epsilon chain;T-cell surface antigen T3/Leu-4 epsilon chain;CD3

Immunogen :

γδTCR-positive T-T hybridoma D1

Specificity :

This antibody recognizes ε/γ (but not ε/δ) of the CD3 complex.

Package Size :

200 μg

Uses :

Flow Cytometry;Immunohistochemistry;Activity Assay;Immunoprecipitation

Storage :

The antibody solution should be stored undiluted at 2-8°C and protected from prolonged exposure to light. Do not freeze.