RIG-I, clone 1C3 | EMD Millipore MABF297 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

RIG-I, clone 1C3

catalog :

MABF297

quantity :

100 μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

1C3

reactivity :

human

application :

western blot, immunocytochemistry, immunoprecipitation

citations: 2

Published Application/Species/Sample/Dilution	Reference
immunoprecipitation; human; loading ...; fig 4a western blot; human; loading ...; fig 3e	Soonthornvacharin S, Rodriguez Frandsen A, Zhou Y, Galvez F, Huffmaster N, Tripathi S, et al. Systems-based analysis of RIG-I-dependent signalling identifies KHSRP as an inhibitor of RIG-I receptor activation. Nat Microbiol. 2017;2:17022 pubmed publisher
	Meyerson N, Zhou L, Guo Y, Zhao C, Tao Y, Krug R, et al. Nuclear TRIM25 Specifically Targets Influenza Virus Ribonucleoproteins to Block the Onset of RNA Chain Elongation. Cell Host Microbe. 2017;22:627-638.e7 pubmed publisher

product information

Catalog Number :

MABF297

Subcategory :

Inflammation & Immunology

Product Name :

Anti-RIG-I, clone 1C3

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

O95786

Host Name :

Mouse

Antigen :

DDX58

Clone :

1C3

Conjugate :

Purified

Purification Method :

Protein G purified

Isotype :

IgG1λ

Product Description :

Anti-RIG-I, clone 1C3

Cross Reactivity :

Human

Background :

Retinoic acid-inducible gene 1 protein (RIG-1) is a cytoplasmic DExD/H box RNA helicase belonging to the helicase family and containing 2 CARD domains within the N-terminus, a repressor domain (RD), a helicase ATP-binding domain and a helicase C-terminal binding domain. RIG-1 is able to bind the 5’-triphosphate RNA of single or double-stranded viral RNA. After recognizing and binding viral RNA, RIG-1 protein initializes type I IFN production, and within fibroblasts and dendritic cells plays a central role in the regulation of type I IFN production in response to viral presence. There are four known isoforms resulting from alternative splice variants.

ALT Names :

Probable ATP-dependent RNA helicase DDX58, DEAD box protein 58, RIG-I-like receptor 1, RLR-1, Retinoic acid-inducible gene 1 protein, RIG-1, Retinoic acid-inducible gene I protein, RIG-I

Immunogen :

Recombinant protein corresponding to human RIG-I.

Package Size :

100 μg

Uses :

Western Blotting, Immunoprecipitation, Immunocytochemistry

Storage :

Stable for 1 year at 2-8°C from date of receipt