IRF3 Antibody, clone SL-12 | EMD Millipore MABF268 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

IRF3 Antibody, clone SL-12

catalog :

MABF268

quantity :

100 μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

SL-12

The same clone is also sold as:

BioLegend: 648701
Santa Cruz Biotechnology: sc-33641, sc-33641 X

reactivity :

human, mouse

application :

western blot, immunocytochemistry, immunoprecipitation

product information

Catalog Number :

MABF268

Subcategory :

Inflammation & Immunology

Product Name :

Anti-IRF3 Antibody, clone SL-12

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

Q14653

Host Name :

Mouse

Antigen :

IRF3

Clone :

SL-12

Conjugate :

Purified

Purification Method :

Protein G purified

Isotype :

IgG1κ

Product Description :

Anti-IRF3 Antibody, clone SL-12

Cross Reactivity :

Human, Mouse

Background :

Interferon regulatory factors (IRFs) comprise a family of transcription factors that function with the Jak/Stat pathway to regulate interferon (IFN) and IFN-inducible gene expression in response to viral infection. IRF-3 can inhibit cell growth and plays a critical role in controlling the expression of genes in the innate immune response. In unstimulated cells, IRF-3 is present in the cytoplasm. Viral infection results in phosphorylation of IRF-3 and leads to its translocation to the nucleus where it activates promoters containing IRF-3-binding sites. Phosphorylation of IRF-3 occurs at a cluster of C-terminal serine and threonine residues (between 385 and 405) leading to its association with the p300/CBP coactivator protein that promotes DNA binding and transcriptional activity.

ALT Names :

Interferon regulatory factor 3, IRF-3

Immunogen :

Recombinant protein corresponding to human IRF3.

Package Size :

100 μg

Uses :

Western Blotting, Immunocytochemistry, Immunoprecipitation

Storage :

Stable for 1 year at 2-8°C from date of receipt