Cochlin Antibody/COCH, clone 9A10D2 | EMD Millipore MABF267 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Cochlin Antibody/COCH, clone 9A10D2

catalog :

MABF267

quantity :

100 μg

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

9A10D2

reactivity :

human, mouse

application :

western blot, immunohistochemistry

citations: 1

Published Application/Species/Sample/Dilution	Reference
western blot; human; fig 3b	Wang Q, Fei P, Gu H, Zhang Y, Ke X, Liu Y. Different Phenotypes of the Two Chinese Probands with the Same c.889G>A (p.C162Y) Mutation in COCH Gene Verify Different Mechanisms Underlying Autosomal Dominant Nonsyndromic Deafness 9. PLoS ONE. 2017;12:e0170011 pubmed publisher

product information

Catalog Number :

MABF267

Subcategory :

Inflammation & Immunology

Product Name :

Anti-Cochlin Antibody/COCH, clone 9A10D2

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

O43405

Host Name :

Rat

Antigen :

COCH

Clone :

9A10D2

Conjugate :

Purified

Purification Method :

Protein G purified

Isotype :

IgG2aκ

Product Description :

Anti-Cochlin Antibody/COCH, clone 9A10D2

Cross Reactivity :

Human, Mouse

Background :

The protein Cochlin/COCH is important in the development of the cochlea and vestibule in mammals as well as other functions. Cochlin/COCH is an extracellular matrix protein that plays a role in cell shape, positioning and motility. Recent research shows that it is also important in our innate immune response to bacteria and pathogens. Upon bacterial infection, a fragment of Cochlin/COCH is released from the conduits of B cell follicles in the spleen and this triggers protective cytokines in the periphery. Cochlin/COCH is expressed in epithelial tissues in various tissues, particularly in follicular cells and network of conduits in the spleen and lymph nodes. Cochlin/COCH also is a target for BMP4 mediation in embryonic stem cells (ESCs) where it facilitates self-renewal. The protein also appears to suppress neural differentiation of ESCs and suggests that Cochlin/COCH protein is important in ES cell fate determination. Mutations in the Cochlin/COCH gene are responsible for human DFNA9 syndrome, a disorder characterized by neurodegeneration of the inner ear that leads to hearing loss and vestibular impairments.

ALT Names :

Cochlin, COCH-5B2

Immunogen :

Recombinant protein corresponding to human Cochlin/COCH.

Package Size :

100 μg

Uses :

Western Blotting, Immunohistochemistry

Storage :

Stable for 1 year at 2-8°C from date of receipt