PAR-1, clone ATAP2 | EMD Millipore MABF244 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

PAR-1, clone ATAP2

catalog :

MABF244

quantity :

100 μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

ATAP2

The same clone is also sold as:

Invitrogen: 35-2200
LifeSpan Biosciences: LS-B2651
Santa Cruz Biotechnology: sc-13503

reactivity :

human, mouse

application :

western blot, immunocytochemistry, flow cytometry

citations: 1

Reference
Wang H, Ricklin D, Lambris J. Complement-activation fragment C4a mediates effector functions by binding as untethered agonist to protease-activated receptors 1 and 4. Proc Natl Acad Sci U S A. 2017;114:10948-10953 pubmed publisher

product information

Catalog Number :

MABF244

Subcategory :

Inflammation & Immunology

Product Name :

Anti-PAR-1, clone ATAP2

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P25116

Host Name :

Mouse

Antigen :

F2R

Clone :

ATAP2

Conjugate :

Purified

Purification Method :

Protein G purified

Isotype :

IgG1κ

Product Description :

Anti-PAR-1, clone ATAP2

Cross Reactivity :

Mouse, Human

Background :

The protein named Proteinase-activated receptor 1 (PAR-1/PAR1) or Coagulation factor II receptor, or Thrombin receptor and encoded by the human gene F2R/CR2R/PAR1/TR is a high affinity receptor for activated thrombin and part of the innate immune system response driven by proteinase-activated receptors (PARs). PARs are G protein-coupled receptors that transmit cellular responses to extracellular proteases and have important functions in vascular physiology, development, inflammation, and cancer progression. PAR1 is important for platelet activation and vascular development. PAR1 expression is limited to platelets and vascular endothelial cells and is localized to the cell membrane. Interestingly too, even the signal peptide of PAR1 (which guides the protein to the membrane) plays a role in cell signaling as if forms the intracellular angiogenesis inhibitor peptide Parstatin.

ALT Names :

Proteinase-activated receptor 1, PAR-1, Coagulation factor II receptor, Thrombin receptor

Immunogen :

Linear peptide corresponding to human Par-1.

Package Size :

100 μg

Uses :

Western Blotting, Flow Cytometry, Immunocytochemistry, Immunofluorescence

Storage :

Stable for 1 year at 2-8°C from date of receipt