Par-2 Antibody, clone SAM11 | EMD Millipore MABF243 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Par-2 Antibody, clone SAM11

catalog :

MABF243

quantity :

100 μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

SAM11

The same clone is also sold as:

BioLegend: 817201
Invitrogen: 14-9699-82, 35-2300
Abcam: ab184673
LifeSpan Biosciences: LS-B2321
Santa Cruz Biotechnology: sc-13504 L, sc-13504

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, flow cytometry

citations: 1

Published Application/Species/Sample/Dilution	Reference
western blot; rat; 1:1000	Bao Y, Hou W, Liu R, Gao Y, Kong X, Yang L, et al. PAR2-mediated upregulation of BDNF contributes to central sensitization in bone cancer pain. Mol Pain. 2014;10:28 pubmed publisher

product information

Catalog Number :

MABF243

Subcategory :

Inflammation & Immunology

Product Name :

Anti-Par-2 Antibody, clone SAM11

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P55085

Host Name :

Mouse

Antigen :

F2RL1

Clone :

SAM11

Conjugate :

Purified

Purification Method :

Protein G purified

Isotype :

IgG2aκ

Product Description :

Anti-Par-2 Antibody, clone SAM11

Cross Reactivity :

Mouse, Human

Background :

The protein named Proteinase-activated receptor 2 (PAR2/PAR-2), or Coagulation factor II receptor-like 1, G-protein coupled receptor 11, Thrombin receptor-like-1 and encoded by the human gene F2RL1/GPR11/PAR2 is a receptor for trypsin and trypsin-like enzymes coupled to G proteins. Its function is mediated through the activation of several signaling pathways including phospholipase C (PLC), intracellular calcium, mitogen-activated protein kinase (MAPK), I-kappaB kinase/NF-kappaB and Rho. Also as part of the innate and adaptive immunity response, PAR2 acts as sensor for proteolytic enzymes generated during infection and works to promote inflammation and the inflammatory response. PAR2 is also involved in vascular and airway tone and in blood pressure regulation and many other G protein coupled receptor response pathways. PAR2 is a multi-pass membrane protein that is widely expressed in most tissues except brain or skeletal muscle.

ALT Names :

Proteinase-activated receptor 2, PAR-2, Coagulation factor II receptor-like 1, G-protein coupled receptor 11, Thrombin receptor-like 1

Immunogen :

Linear peptide corresponding to the N-terminus of human Par-2.

Package Size :

100 μg

Uses :

Western Blotting, Immunohistochemistry, Flow Cytometry

Storage :

Stable for 1 year at 2-8°C from date of receipt